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Metabolic Pathways

Explore the thermodynamics of ATP hydrolysis, enzyme mechanisms, stages of catabolism, and more in metabolic pathways. Learn about phosphorylation, citric acid cycle, and energy production. Understand catabolism and anabolic pathways.

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Metabolic Pathways

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  1. Metabolic Pathways Chapter 26

  2. Metabolic Pathways – Ch. 26 1. List three reasons why the hydrolysis of ATP into ADP and phosphate is so thermodynamically favorable:

  3. Metabolic Pathways – Ch. 26 2. Why is the rate of nucleophilic attack on ATP (ex hydrolysis) significantly faster in an enzyme?

  4. Metabolic Pathways – Ch. 26 3. An enzyme that catalyzes phosphorylation is called a _______________. Compare and contrast the 3 possible mechanisms for phosphorylation of a fatty acid in order to attach it to coenzyme A.

  5. Metabolic Pathways – Ch. 26 4. List and describe the four stages of catabolism:

  6. Metabolic Pathways – Ch. 26

  7. Metabolic Pathways – Ch. 26 5. For every one molecule of glucose that undergoes glycolysis__________ molecules of pyruvate, __________ ATP molecules and ____________ NADH.

  8. Metabolic Pathways – Ch. 26 6. What causes lactic acid build up?

  9. Metabolic Pathways – Ch. 26 7. Before pyruvate can enter the citric acid cycle it must be converted to _________________ by 3 enzymes and the 5 coenzymes ___________, ______________,_____________,_____________ and _______________ in the pyruvate dehydrogenase system

  10. Metabolic Pathways – Ch. 26 8. In the first step of catabolism; fats are hydrolyzed into ____________ and ______________. Catabolism of 1 molecule of palmitic acid (fatty acid with 16 carbons) produces ___________ acetyl CoA molecules______________ FADH2 molecules and ___________ NADH molecules.

  11. Metabolic Pathways – Ch. 26

  12. Metabolic Pathways – Ch. 26 9. The overall reaction for the citric acid cycle is ______________________________________ which produces ______________ molecules of ATP________________molecules of NADH and _________________molecules of FADH2 for every molecule of acetyl CoA.

  13. Metabolic Pathways – Ch. 26 10. Stage 4 of catabolism is _________________________ in which 1 molecule of NADH produces ___________ molecules of ATP and 1 molecule of FADH2 produces ____________ molecules of ATP. Therefore for each molecule of acetyl CoA that enters the citric acid cycle ____________ molecules of ATP are produced. For every 1 molecule of glucose that is catabolized ___________ molecules of ATP are produced. For every 1 molecule of palmitic acid that is catabolized_______ molecules of ATP are produced.

  14. Metabolic Pathways – Ch. 26 11. What is the majority type of reactions in the anabolic pathways?

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