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The International Centre for Genetic Engineering and Biotechnology

The International Centre for Genetic Engineering and Biotechnology. This course is sponsored by. Welcome. Advanced Bioinformatics:. Computational Systems Biology. Fernando Alvarez, Alberto Ferrarini, Massimiliano Gentile, Attila Kert ész Farkas , Mike Myers, S ándor Pongor.

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The International Centre for Genetic Engineering and Biotechnology

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  1. The International Centre for Genetic Engineering and Biotechnology This course is sponsored by Welcome

  2. Advanced Bioinformatics: Computational Systems Biology Fernando Alvarez, Alberto Ferrarini, Massimiliano Gentile, Attila Kertész Farkas, Mike Myers, Sándor Pongor Course assistant: Mircea Pacurar Secretariat: Elisabetta Lippolis Chiara Alberti Accounts: Giulia Bon, Lisa Sessi Barbara Leggieri Computer system manager: Dario Palmisano Diego Soldano Trieste, 3-7 October, 2011

  3. ICGEB programs • Research • Training: Ph.D., postdoctoral and specialized courses • Research grants • Services: Bioinformatics, Biotech process development, Biosafety consulting

  4. Participants 400 350 300 250 200 150 100 50 0 1988 1989 1990 1996 1998 2002 2003 2004 2005 2006 2007 ICGEB courses • 12-15 courses yearly • Theoretical courses (50 students) and practical courses (up to 30 students) • Mainly molecular biology

  5. Protein Structure and Bioinformatics • Established as a resource group for protein chemistry and protein engineering • In charge of bioinformatics services since 1991 • Research projects on bioinformatics, structural biology, systems modelling, bacterial communication • Currently includes 12 researchers and students

  6. ICGEB bioinformatics • Biological computing service for 800 users from 35 countries • 2-3 training courses per year, 1500+ students in 20 years... • Methods development (classification, machine learning) • WWW-services: DNA-tools, protein domain identification

  7. Advanced Bioinformatics: Computational Systems Biology Fernando Alvarez, Alberto Ferrarini, Massimiliano Gentile, Attila Kertész Farkas, Mike Myers, Sándor Pongor Course assistant: Mircea Pacurar Secretariat: Elisabetta Lippolis Chiara Alberti Accounts: Giulia Bon, Lisa Sessi Barbara Leggieri Computer system manager: Dario Palmisano Diego Soldano Trieste, 3-7 October, 2011

  8. Molecular biology Systems biology

  9. Approaches based on data collection Traditional wet lab methods High throughput technologies

  10. Bioinformatics I • Computer support for traditional molecular biology (cloning, sequencing). • Concentrates on singe genes and proteins. Well-defined problems, small, validated datasets. • Compares single genes, gene groups • “Simple databases” Annual bioinformatics course „Computer methods in molecular biology”

  11. Bioinformatics II • Computer support for high throughput technologies (genomics, proteomics). • Concentrates on system-wide responses. Vaguely defined problems, large raw datasets. • Compares complex data (genomes, gene expression profiles etc). • Uses both traditional and complex, integrated databases. ...This course

  12. The problems • Many different data-collection methods • Method-specific approaches (programs, data-formats etc.) • Short life-span of individual methods. • No unified teaching perspective

  13. This course • Next Generation Sequencing (Mon-Tue) Fernando Alvarez (Montevideo) Alberto Ferrarini (Verona) Massimiliano Gentile (Helsinki) • Proteomics (Wed-Thu) Michael P. Myers (ICGEB) Attila Kertész-Farkas (ICGEB) • Genome annotation (Fri) Laurent Falquet (Lausanne)

  14. The International Centre for Genetic Engineering and Biotechnology This course is sponsored by Welcome

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