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Glycoproteins and Proteoglycans

Glycoproteins and Proteoglycans. Eric Niederhoffer SIU-SOM. Proteins conjugated to saccharides lacking a serial repeat unit. Glycoproteins. Protein >> carbohydrate. Proteins conjugated to polysaccharides with serial repeat units. Proteoglycans. Carbohydrate >> protein. Glycosaminoglycans

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Glycoproteins and Proteoglycans

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  1. Glycoproteins and Proteoglycans Eric Niederhoffer SIU-SOM Proteins conjugated to saccharides lacking a serial repeat unit Glycoproteins Protein >> carbohydrate Proteins conjugated to polysaccharides with serial repeat units Proteoglycans Carbohydrate >> protein Glycosaminoglycans Mucopolysaccharides Repeat unit HexN and HexUA

  2. Glycopeptide bonds Asn Glc NAc Type I N-Glycosyl linkage to Asn Ser HOLys Glc Glc NAc Type II O-Glycosyl linkage to Ser (Thr) Type III O-Glycosyl linkage to 5-HOLys

  3. b-1,3 b-1,4 Glycosaminoglycans GlcUA GlcNAc No protein link No sulfate b-1,3 glycosidic linkage Hyaluronate

  4. b-1,3 b-1,4 Glycosaminoglycans GlcUA GalNAc GlcUA-Gal-Gal-Xyl-O-Ser link Sulfate at 4 or 6 C of GalNAc b-1,3 glycosidic linkage Chondroitin sulfate

  5. b-1,3 b-1,4 Glycosaminoglycans IdUA GalNAc IdUA with some GlcUA Sulfate at 4 or 6 C of GalNAc b-1,3 glycosidic linkage Dermatan sulfate

  6. a-1,4 a-1,4 Glycosaminoglycans GlcUA GlcNAc GlcN and GlcUA or IdUA N and O sulfate (C2,3,6) a-1,4 glycosidic linkage Heparin > NAc < N and O sulfate Heparan sulfate

  7. b-1,4 b-1,3 Glycosaminoglycans GlcUA GlcNAc GlcNAc and Gal (no UA) Sulfate on C6 of Gal or HexN b-1,4 glycosidic linkage Keratan sulfate I Keratan sulfate II GalNAc-O-Ser or Thr

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