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Boceprevir with PEG + RBV in Genotype 1 SPRINT -1

Phase 2. Treatment Naïve. Boceprevir with PEG + RBV in Genotype 1 SPRINT -1. Kwo PY, et al. Lancet. 2010;376:705-16. Boceprevir for Treatment-Naïve HCV Genotype 1 SPRINT -1 Trial: Part 1.

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Boceprevir with PEG + RBV in Genotype 1 SPRINT -1

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  1. Phase 2 TreatmentNaïve Boceprevir with PEG + RBV in Genotype 1SPRINT-1 Kwo PY, et al. Lancet. 2010;376:705-16.

  2. Boceprevir for Treatment-Naïve HCV Genotype 1SPRINT-1 Trial: Part 1 Drug DosingBoceprevir = 800 mg three times dailyPeginterferon alfa-2b = 1.5 µg/kg once weeklyRibavirin = 800-1400 mg/day (based on weight)Ribavirin = 400-1000 mg/day (low dose) Source: Kwo PY, et al. Lancet. 2010;376:705-16.

  3. Boceprevir for Treatment-Naïve HCV Genotype 1SPRINT-1 Trial, Part 1: Design 0 4 12 24 28 48 Week PR48 N=104 Peginterferon + Ribavirin (weight-based) N=103 PR4PRB24PR28 Boceprevir Peginterferon + Ribavirin (weight-based) N=103 PR4PRB44 Boceprevir Peginterferon + Ribavirin (weight-based) N=107 PRB28 Boceprevir Peginterferon + Ribavirin (weight-based) PRB48 Boceprevir N=103 Peginterferon + Ribavirin (weight-based) Source: Kwo PY, et al. Lancet. 2010;376:705-16.

  4. Boceprevir for Treatment-Naïve HCV Genotype 1SPRINT-1 Trial, Part 1: Results SPRINT-1, Part 1: SVR 24 by Regimen 39/104 58/103 77/103 58/107 69/103 B = Boceprevir; PR = Peginterferon+ Ribavirin Source: Kwo PY, et al. Lancet. 2010;376:705-16.

  5. Boceprevir and Peginterferon plus Ribavirin for Chronic HCV SPRINT-1 Trial, Part 2: Design 0 12 24 48 Week PRB48 Boceprevir N=16 Peginterferon + Ribavirin (weight based) Low-DosePRB48 Boceprevir N=59 Peginterferon + Low-Dose Ribavirin (low dose) Source: Kwo PY, et al. Lancet. 2010;376:705-16.

  6. Boceprevir and Peginterferon plus Ribavirin for Chronic HCV SPRINT-1 Trial, Part 2,: Results SPRINT-1: SVR 24 by Ribavirin Dosing 8/16 21/59 P = Peginterferon; R = Ribavirin; B = Boceprevir Source: Kwo PY, et al. Lancet. 2010;376:705-16.

  7. Boceprevir and Peginterferon plus Ribavirin for Chronic HCV SPRINT-1 Trial: Conclusions Source:Kwo PY, et al. Lancet. 2010;376:705-16.

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