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Involvement of PARP-1 in the inflammatory response at two different levels

Lipopolysaccharide. P. MACROPHAGE (1). iKK. i k B a. k Bi a. PARP-1. TARGET CELL (2) (Endothelial cell). NF- k B. NF- k B. pro-inflammatory cytokines :. IL-1; IL-6; TNF- a. Saturating DNA damage. iNOS. PARP-1. Overactivation. NAD + depletion. NO. Systemic inflammation.

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Involvement of PARP-1 in the inflammatory response at two different levels

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  1. Lipopolysaccharide P MACROPHAGE (1) iKK ikBa kBia PARP-1 TARGET CELL (2) (Endothelial cell) NF-kB NF-kB pro-inflammatory cytokines : IL-1; IL-6; TNF-a Saturating DNA damage iNOS PARP-1 Overactivation . NAD+ depletion NO . Systemic inflammation Cell death Necrosis _ Septic shock ONOO ATP consumption O2 Involvement of PARP-1 in the inflammatory response at two different levels Oliver et al. (1999) EMBO.J., 18, 4446 - 4454)

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