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CCE project update

CCE project update. Metabolomics Raftery Group. Original Study. 20 cancer, 28 normals and 14 with polyps NMR and GC-MS study. CCE Samples and Experiments. 110 Samples received (104 patients). 1 H NMR experiment. Multivariate analysis.

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CCE project update

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  1. CCE project update Metabolomics Raftery Group

  2. Original Study 20 cancer, 28 normals and 14 with polyps NMR and GC-MS study

  3. CCE Samples and Experiments • 110 Samples received (104 patients) • 1H NMR experiment

  4. Multivariate analysis • 26 metabolites quantified; 8 showed p<0.05 between cancer and normal • Unsupervised analysis on all samples showed little difference • Supervised analysis in progress. Shows some separation but needs additional MS data • more cancer samples needed for better discrimination model.

  5. Seven metabolite model built on previous colon sample (17 Cancer, 17 Healthy), • predict on CCE samples (14 Cancer, 46 Healthy, 32 Polyps) • Looks like colon cancer samples are failing, but many were collected after surgery. • Could be showing some treatment effect. • Q1: For those samples collected on the day of treatment, which were drawn before therapy or surgery? • Q2: Are CCE samples collected as the same way as previous samples?

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