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KOMPOSISI KIMIAWI KULIT

KOMPOSISI KIMIAWI KULIT. KOMPOSISI KIMIA KULIT. Konstituen kulit Protein Non Prot : Air, Lipida, KH, Enzim, Vitamin, Mineral Air ± 65 % Prot ± 33 % Lemak ± 1,8 % Mineral ± 0,2 % AIR a). Air terikat dalam prot pertahanan stabilitas & bntk

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KOMPOSISI KIMIAWI KULIT

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  1. KOMPOSISI KIMIAWI KULIT

  2. KOMPOSISI KIMIA KULIT Konstituen kulit Protein Non Prot : Air, Lipida, KH, Enzim, Vitamin, Mineral Air ± 65 % Prot ± 33 % Lemak ± 1,8 % Mineral ± 0,2 % AIR a). Air terikat dalam prot pertahanan stabilitas & bntk b). Air dalam papillaris sbg cadangan - Lap. Corium > Lap Epidermis - tiap-tiap bagian/peta kulit kandungan air berbeda - bagian perut > leher > croupon

  3. KIMIAWI KULIT • SBG PELINDUNG - EPIDERMIS • - KORIUM • BERBEDA SUSUNAN / KOMP KIMIAWI • Prot • Lemak • Enzim • KH • AIR, Mineral • Epidermis ephitel pipih berlapis • - Prot fibous KERATIN • - Sebum sekresi kel lemak • - KH sel kelenjar, sel rambut • sel malphigi • - zat warna melanin sel melanocyte

  4. LAP KORIUM • SEL, SERABUT, SUBSTANSI DASAR, CAIRAN JARINGAN • KOMPONEN KIMIAWI Prot Fibrus • 80-90 % - Prot Kolagen ser kolagen • - Prot Elastin ser elastin • - Prot Retukulin ser retikular • Prot globular Pengisi antar serabut • + Substansi dasar • KH CAIRAN JARINGAN • Mineral - >< bahan an org jaringan • - larut dlm substansi dasar cairan jaringan • Enzim katepsin • Prokolagenase • Air air terikat • bebas

  5. Kulit hewan

  6. SERABUT KOLAGEN • Tensile Strength 10 – 40 kg/ 1 mm • - struktur triple helix tropokolagen & Polimerisasi KOLAGEN • Bentuk triplehelix dr polipeptida Axis Residu Glycine • Ikatan imino peptida, peptida linkyi prolin & hidroksiprolin • Ikatan Hidrogen – gugus OH Hid Prol antar polipeptida dg H2O jembatan antar rantai polipeptida fibril kolagen • Gaya tarik Van der wall • Lysin Produk aldehid Aldol condensation products

  7. SINTESIS KOLAGEN • IN SEL FIBROBLAST • - Transkripsi sintesis kolagen (mRNA) • - Sintesis polipeptida • - Hidroksilasi Prolin & Lisin • - Glikolisasi Hidroksilisin • tbtk prokolagen • LUAR SEL FIBROBLAST • - pemutusan kelebihan Peptida ujung Prokolagen Prokolagen Peptidase • tbtk Tropokolagen • lysel oxydase kolagen – CHO • Pembentukan CROSS-LINK SERABUT KOLAGEN

  8. Retikulin • SUSUNAN = KOLAGEN • STRUKTUR SERABUT = KLAGEN TIPIS • Tssnsptjalamengelilingikolagen • Elastin • serabutelastis • mudahdiregangkandalamkeadbasah • dalamkeadkeringkaku, keras, dayaregang • Tdptpembuluhdarah • aorta • ligamentum • Glycine 33 % • Proline & Hid Prot • # Hid lisin • Residualipatik • Lysinonorleucine • Desmosin • dsbtfibrilomembranosusdinding abdomen Elastisitas, peregangan

  9. KOLAGEN • FIBRIL SERABUT KOLAGEN • POLIMER • TROPOKOLAGEN • P 280 – 300 nm • T 1,5 nm • sejajar / memanjang searah dg panjang serabut • Karakteristik : • Glycine 33 % • Residu Imino • Hidroksiproline • Hidroksilisine • - G – X – HP – G – X – LYS – G – X – Y • # redisu aromatik • # Triptopan • AA S • Galaktosa & Glukosa Glycosyl • Galaktosit – O - Hydroksilisin AA ttn Glycine Hid Pro

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