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Urinary System. Functions. 1 . Excretion Elimination Homeostatic Regulation. Metabolic Wastes. Urea Creatinine Uric Acid. Urinary System. Kidney regions: Cortex Direct filtration cortical nephrons juxtamedullary nephrons 2. Medulla Reabsorption , Secretion Pelvis
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Functions 1. Excretion • Elimination • Homeostatic Regulation
Metabolic Wastes • Urea • Creatinine • Uric Acid
Urinary System • Kidney regions: • Cortex • Direct filtration • cortical nephrons • juxtamedullarynephrons 2. Medulla • Reabsorption, Secretion • Pelvis excretion
Overview of Urinary System • Flow • Filtration • Reabsorption • Secretion
Glomerular Filtration • Filtration membrane • Net Filtration Pressure: • Glomerular hydrostatic pressure (HPg) (GBHB) • Colloid osmotic pressure (OPg) (BCOP) • Capsular hydrostatic presure (HPg) (CHP) • Glomerular Filtration Rate (GFR)
Tubular Reabsorption • Reabsorption of organic nutrients • Reabsorption of ions, water, and some molecules. • Water reabsorption- osmotic changes due to active transport of sodium ions. • Molecule reabsorption - secondary active transport initiated by ions. Types of Active Transport • Co-transport • Countertransport
Types of carrier mediated transport • Facilitated diffusion • Active Transport (secondary active) • Cotransport(symport) • Countertransport(antiport)
Tubular Secretion • Disposes of unwanted solutes • Regulation of Urine Concentration and Volume • countercurrent mechanism • osmotic gradients • Diuretics
Maintaining Homeostasis Balances: Water/salt pH Blood pressure