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Grapes Health

Health Studies in PubMed. Grapes and Health 280 publicationsRaisins and Health 188Wine and Health 1316Wine 9655 Red Wine" 1650 Resveratrol and Health 335Resveratrol 2708. Health and Nutrition. Components of grapes/wine that can enhance human health and provide for the nutr

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Grapes Health

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    1. Grapes & Health David M. Klurfeld ARS National Program Leader, Human Nutrition

    2. Health Studies in PubMed Grapes and Health – 280 publications Raisins and Health – 188 Wine and Health – 1316 Wine – 9655 “Red Wine” – 1650 Resveratrol and Health – 335 Resveratrol – 2708

    3. Health and Nutrition Components of grapes/wine that can enhance human health and provide for the nutritional needs of the American public Compounds may need to be delivered as a package to derive maximal benefit Health and nutrition concerns will be strong drivers for the market of both traditional and innovative products

    4. Health Attributes Antioxidants Antioxidants Antioxidants Red wine – heart disease Still controversial – AHA says no specific link Grape/wine reduction of blood clotting Ethanol has similar effect

    6. Effects of Grape Products on Early Steps of Atherosclerosis

    7. CSREES-funded Grape Study Chemical characterization of red wine grape (Vitis vinifera and Vitis interspecific hybrids) and pomace phenolic extracts and their biological activity against Streptococcus mutans. Thimothe J, Bonsi IA, Padilla-Zakour OI, Koo H J Agric Food Chem. 2007 Dec 12;55(25):10200-7.

    8. ARS Research on Grapes WHNRC – Davis, CA Resveratrol induces apoptosis in acute lymphoblastic leukemia cells in vitro Following up with mice injected with ALL cells Resveratrol inhibits toll-like receptor 4-induced inflammation in cultured cells

    9. ARS Research on Grapes HNRCA at Tufts University Comparing juices from: Concord – both anthocyanins & proanthocyanidins Niagara – only proanthocyanidins Thompson – neither polyphenol class 5 tests of psychomotor function

    11. Flow-Mediated Dilation and Freeze-Dried Grape Powder

    12. Flow-Mediated Dilation and Freeze-Dried Grape Powder

    13. Flow-Mediated Dilation and Freeze-Dried Grape Powder

    15. Alcohol and RBC n-3 Fatty Acid Index

    16. Mortality in 2468 Finnish men with 29-yr follow-up

    17. Correlation ? Proof

    18. It’s Not Just Resveratrol Quercetin used to be king of the compounds >1600 compounds in grapes Concentrations in wine differ from juice Equivalents in both animal and human studies range up to pounds/day or 300 bottles of wine “All things are poison and nothing is without poison, only the dose permits something not to be poisonous” – Paracelsus (1493-1541)

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