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Silk arterial reconstruction for intracranial aneurysms. Multicentric french study on 51 consecutive patients.

Silk arterial reconstruction for intracranial aneurysms. Multicentric french study on 51 consecutive patients. Jérôme Berge, Alain Bonafé, Hervé Brunel, Emmanuel Chabert, Jean Gabrillargues, Kristof Kadziolka, Xavier Barreau, Laurent Pierrot, Vincent Dousset. Neuroradiology Departments:

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Silk arterial reconstruction for intracranial aneurysms. Multicentric french study on 51 consecutive patients.

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  1. Silk arterial reconstruction for intracranial aneurysms.Multicentric french study on 51 consecutive patients. Jérôme Berge, Alain Bonafé, Hervé Brunel, Emmanuel Chabert, Jean Gabrillargues, Kristof Kadziolka, Xavier Barreau, Laurent Pierrot, Vincent Dousset. Neuroradiology Departments: Bordeaux, Montpellier, Marseille, Clermont-Ferrand, Reims, France

  2. Aims • Clarify indications for new flow diverters • Regarding the aneurysm location • Regarding aneurysm size • Without any scientific litterature in 2009 ! • Evaluate morbi-mortality of Silk stent on a retrospective multicentric group. • Evaluate angiographic occlusion rate in post-procedure and at 6 months.

  3. How can we justify to take risk on a non ruptured aneurysm ? • 3 criteria to take into account: • Patient age • Life expectancy • endovascular acces faisability • aneurysm symptomatic or not ? • Seizures • Nerve palsy or compressive syndrom • Rupture rate associated with aneurysm • Risk factors • Regrowth of a previous treated aneurysm • Smoker, elevated blood pressure, history of SAH, • size and localisation of aneurysm

  4. Population • I.S.U.I.A. study (2003) • Cumulated rupture rate at 5 years • In a patient without history of SAH Lancet. 2003 Jul 12;362(9378):103-10. Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. Wiebers DO …… « International Study of Unruptured Intracranial Aneurysms Investigators ».

  5. Patients • data from 5 centers on a 1 year period • 51 patients (10 M + 41 F): average = 53 years old • Average diameter of the sac = 18,1 mm • Non ruptured IC aneurysms : 15 fusiforms, 34 sacciforms and 2 dissecting aneurysms. • 11 regrowth post embolisation after SAH • Clinical data: • 23 asymptomatic patients • 28 patients with compressive symptoms. • Cavernous sinus: 15 / 22 C.C. aneurysms • Brainstem: 4 / 7 vertebro-basilar aneurysms • Optic nerve and chiasma: 9 / 19 ophtalmic aneurysms

  6. Distribution of patients /size and localization of the aneurysm

  7. Why did we treat small carotid aneurysms ? • 9 carotid ophtalmic aneurysms < 12 mm • Both of them had optic nerve compression • 2 recanalisations of previous treated aneurysms • 4 dysplastic carotids with 2 to 5 aneurysms • 1 case had associated ruptured aneurysm

  8. Methods • 51 endovascular procedures: • 33 cases with 1 Silk • 5 patients with regrowth after Neuroform + coils • 6 cases with 2 silk • 10 cases with Silk + coils, • 2 cases with coils in controlateral feeder • Opposite ACA on ACom aneurysm, opposite vertebral artery • 1 case with 2 Silk and coils • 2 cases: Silk with poor deployment • Requiring use of a Neuroform or Enterprise stent

  9. Angiographic results Kamran-Byrne classification 2010 (Plos One) : 88% at 6 months : 5 stenoses at 50%: (all asymptomatic)

  10. Clinical results • Acute morbidity  : 5 strokes • 2 cases: poor deployment of the FD Stent • 3 cases: thrombosis of the stent and embolic events • Delayed morbidity: • 19 post procedure inflammatory adverse events. • (see previous communication yesterday) • 2 TIA at 3 months when Plavix was stopped • 3 bleeding complications : (day 14, 3 and 4 months) • 1 patient died (rebleeding at 3 months) • 2 carotid-cavernous fistula (day 14 and 4months) • With successfull endovascular treatment • Rupture happened on occluded prooved aneurysms Mortality at 6 months = 1 / 51 patient (2 %) Permanent morbidity = 5 strokes / 51 patients (9,8%)

  11. Relationship between morbi-mortality and aneurysm location

  12. Discussion about complications: • 6 parent artery occlusions • 5 cases of SILK poor delivery • use of Neuroform or Entreprise stents in 2 patients • 5 occured in the carotid siphon and 1 MCA • Responsible for: 4 strokes 2 asymptomatic occlusions • 4/5 strokes on carotid siphon aneurysms • 2 on carotid cavernous aneurysms • 2 on carotid ophtalmic aneurysms • 1 on MCA • 1 resistance to clopidogrel • All this events were related with delivery of the SILK stent on a tight curved artery > 90°

  13. Conclusion • Flow diversion is a promising technique for the treatment of giant or broad neck or fusiform aneurysms. • Acute stroke is the main risk: • Related to poor deployment in curved arteries • Or resistance to antiplatelet treatment. • Transient compressive syndrom and delayed bleeding risk remain ununderstood challenges.

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