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Base excision repair is impaired in PARP-1 deficient cells

Base Excision Repair (BER). Short Patch Repair (SPR) Incorporation of one nucleotide at the site of the lesion Long Patch Repair (LPR) Incorporation of several nucleotides after strand displacement on the 3 ’ side of the lesion. Base excision repair is impaired in PARP-1 deficient cells.

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Base excision repair is impaired in PARP-1 deficient cells

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  1. Base Excision Repair (BER) • Short Patch Repair (SPR) • Incorporation of one nucleotide • at the site of the lesion • Long Patch Repair (LPR) • Incorporation of several nucleotides • after strand displacement on the • 3 ’ side of the lesion Base excision repair is impaired in PARP-1 deficient cells origin of uracil 8-oxoG AP site BER pathway SPR+LPR LPR SPR+LPR LPR genotype +/+ -/- +/+ -/- +/+ -/- +/+ -/- 1.0 0.8 Relative repair efficiency 0.6 0.4 0.2 0.0 Dantzer, F. et al. (1999) Biochimie, 81, 69 - 85 Dantzer, F. et al. (2000) Biochemistry, 39, 7559 - 7569

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