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Investor Presentation January 2011

Forward-Looking Statements. 2. This press release contains forward-looking statements that reflect the Company's current expectations regarding future events. These forward-looking statements involve risks and uncertainties, many of which are beyond the Company's control. Actual events could differ materially from those projected herein and depend on a number of risks and uncertainties, including risks related to the Company's ability to complete partnering transactions and the terms of any such32210

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Investor Presentation January 2011

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    2. Forward-Looking Statements

    5. OLEPTRO™

    6. OLEPTRO™

    14. Global Commercialization Plan

    15. Once-Daily Tramadol

    16. Global Tramadol Franchise

    17. BID Tramadol-Acetaminophen

    18. Nearing Commercialization

    21. Addressing the Need

    22. BID Oxycodone-Acetaminophen

    23. First Marketing Partnerships

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