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Chromosomes Analysis. Fruit Fly. Why Fruit Flies? . Small size Easy to handle Short generation time (10 – 12 days) Many offspring Many variations or mutations 4 pairs of chromosomes 100 times larger than human chromosomes. Chromosome Mapping.
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Chromosomes Analysis Fruit Fly
Why Fruit Flies? • Small size • Easy to handle • Short generation time (10 – 12 days) • Many offspring • Many variations or mutations • 4 pairs of chromosomes • 100 times larger than human chromosomes
Chromosome Mapping • Thomas Hunt Morgan 1st used fruit flies in 1907 and in 1911 he recognized that the banding patterns were constant in their location and number. • Morgan also noticed that any irregularity in the banding pattern was reflected in abnormal fruit flies • After many years of research geneticists chromosome maps were constructed
Mutations • 1921 – H. J. Muller discovered that genes can mutate • He induced mutations in fruit flies by exposing them to x-rays.
Drosophila Chromosomes • 4 chromosomes • The 1st chromosome is the X chromosome • Chromosome numbers 1- 3 are large and chromosome number 4 is extremely small • The chromosomes contain thousands of gene of which only 48 will be included in our map • Many of these genes are also found in humans
X chromosome – chromosome 1 • White Eye • Vermillion Eye • Bar Eye • Hexokinase
Chromosome 2 • Dumpy Wing • Black Body • Cinnabar Eye • Vestigial Wing
Chromosome 3 • Sepia Eye • Scarlet Eye • Hairless • Ebony Body
Chromosome 4 • Eyeless