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Cellular response to DNA damage

Cellular response to DNA damage. Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal of DNA damage Enzymatic photoreactivation

oren-william
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Cellular response to DNA damage

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  1. Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal of DNA damage Enzymatic photoreactivation Repair of O6-alkylguanine, O4- alkyltimidine Ligation of DNA strand breaks Excision of DNA damage Base Excision Repair Nucleotide Excision Repair Mismatch Repair Double strand breaks ligation Single strand annealing Recombinational Repair Non-Homologous End Joining

  2. La radiazione Solare può essere distinta in 3 componenti principali a seconda della lunghezza d’onda:ULTRAVIOLETTO (100-400 nanometri) 10% VISIBILE ( 400-750nm.) 45%INFRAROSSO (750-3000nm.) 45% Spettro della radiazione solare

  3. UV-induced damage

  4. UV-responsive photolyases

  5. Direct reversal (de-alkylating proteins)

  6. Base Excision Repair

  7. Nucleotide Excision Repair (E.coli)

  8. Nucleotide Excision Repair (Global Genome Repair -Humans)

  9. Nucleotide Excision Repair(Transcription Coupled -Humans)

  10. Common features of GGR & TCR

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