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4 December 2009 Respiratory Physiology

4 December 2009 Respiratory Physiology. Lab next week: Urinalysis Review website for instructions. Look over Chapter 14 this weekend!. About the Final Exam….. Choice of Tuesday or Wednesday 9-noon Details of format and suggestions are posted to the website. Schedule Change for Spring

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4 December 2009 Respiratory Physiology

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  1. 4 December 2009Respiratory Physiology Lab next week: Urinalysis Review website for instructions. Look over Chapter 14 this weekend!

  2. About the Final Exam….. Choice of Tuesday or Wednesday 9-noonDetails of format and suggestions are posted to the website. Schedule Change for Spring Biology 484 Human Ecology = Sociology 225 3 hr Biology Elective Optional 1 hr lab if you want/need a 4 hour Bio course With Dr. Abercrombie

  3. Abstracts Pick up in Milliken 204 this afternoon from 1:30 – 4:30. Anonymously graded Grade average so far is 79 Max = 99 So far, 8 of 50 abstracts in the 90’s How to address an unsatisfactory grade: see which sections most points were lost, and concentrate on improving these sections. Revised abstract due Wednesday Exam Day at 9:00 am. Submit revised abstract, original abstract, original stats report, and 1st Grading rubric all paper-clipped in this order. Overall abstract grade proportion to be determined.

  4. Steep Flat

  5. Shifting the Oxyhemoglobin dissociation curve At 40 Torr, more DPG, higher temperature, and greater acidity (all indicative of increased metabolism) shift dissociation curve down (Hb has a lower affinity for O2) and thus more O2 is unloaded into the tissues. Notice the main affect is on the steep portion of the curve which means that there is little influence on the loading of O2 onto Hb in the lungs

  6. Table 13.09

  7. For negative feedback, 1 What is the stimulus?2 Where should the receptors be located?

  8. Peripheral Chemoreceptors • Carotid bodies (not carotid sinuseswhich are baroreceptors) • Aortic bodies (not aortic arch baroreceptors) Central Chemoreceptors in medulla To ponder: Why should there be three sets of chemoreceptors?

  9. Carbon Dioxide reacts with water! CO2 + H20 ↔ H2CO3 ↔ H+ + HCO3- Carbonic Acid Bicarbonate H+ can’t cross Blood Brain Barrier but CO2 does!

  10. Figure 13.36

  11. CO2 + H20 ↔ H2CO3 ↔ H+ + HCO3- Carbonic Acid Bicarbonate

  12. Figure 13.34

  13. Figure 13.22

  14. Figure 13.32 Negative feedback loop for control of blood gases Cervicalspinal cordinjury

  15. Figure 13.40 Name the components of the negative feedback loop

  16. Respiratory Physiology during Exercise Blood gases and pH change very little except when exercise is intense. Therefore, changes in minute ventilation are not the result of negative feeback. How can this be?

  17. Negative feedback operates! But the changes in ventilation at the onset and offset of exercise cannot be explained by negative feedback. Experience, learning, modification of motor program, feed forward!

  18. Figure 13.43 Integrator

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