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MM. pSPL3. MM. pSPL3. 800 bp. 500 bp. 700 bp. 450 bp. 600 bp. 400 bp. 500 bp. 350 bp. 400 bp. 300 bp. 300 bp. 250 bp. HeLa. COS-7. Supplementary Figure S1. Coelho et al (2014). exon 9. exon 9. gt cagtctc cca g gt aggatcctggggc. exon 8. 3’- gt c ca tcctaggacc - 5’. LNA1.
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MM pSPL3 MM pSPL3 800 bp 500 bp 700 bp 450 bp 600 bp 400 bp 500 bp 350 bp 400 bp 300 bp 300 bp 250 bp HeLa COS-7 Supplementary Figure S1 Coelho et al (2014)
exon 9 exon 9 gtcagtctcccaggtaggatcctggggc exon 8 3’- gtccatcctaggacc - 5’ LNA1 10 nt gtcagtctcccaggtaggatcctggggc exon 8 3’- agagggtccatcctag - 5’ LNA2 5 nt Supplementary Figure S2 Coelho et al (2014)
-LNA +LNA1(0.5 μM) MM 400 bp 300 bp Supplementary Figure S3 Coelho et al (2014)
A p.D274Gfs*17 WT ~45 kDa ~35 kDa B C Supplementary Figure S4 Coelho et al (2014)
A Denatured protein (normalized) [θ] (mdeg.cm-2.dmol-1) a b a b B T (°C) λ (nm) T (°C) C b b a Aggregated protein (normalized) Aggregated protein (normalized) a D T (°C) Time (min) Supplementary Figure S5 Coelho et al (2014)
