1 / 5

On-TIME 2

On-TIME 2. Objective: To investigate whether the results of primary PCI can be improved by early administration of high bolus dose tirofiban at first medical contact ( ambulance or referral center).

skylar
Download Presentation

On-TIME 2

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. On-TIME 2 Objective: To investigate whether the results of primary PCI can be improved by early administration of high bolus dose tirofiban at first medical contact (ambulance or referral center). Study: Phase 1 open label randomized(tirofiban/ no tirofiban), Phase 2 randomized, placebo controlled trial. Population: STEMI patients, symptoms < 24 hours. Endpoint: MACE at 30 days (Death, re-MI, urgent TVR).

  2. Phase 1 N=414 Tirofiban High bolus+ infusion+ASA+ heparin+clopidogrel N=709 Transport to PCI center PCI Phase 2 N=984 Placebo/notirofiban (Bolus+infusion)+ASA+ heparin+clopidogrel n=689 On-TIME 2

  3. On-TIME 2 Eventrate at 30 days (%) p=0.043 p=0.051 p=0.66 p=0.01 p=0.58

  4. On-TIME 2 Deathrate at 1 year (%) p=0.078 p=0.061 p=0.77

  5. On-TIME 2 Conclusion: Early, pre-hospital initiation of high-bolus tirofibanimproved clinical outcome after primary PCI in patients with STEMI. Ten Berg et al. J Am CollCardiol 2010;55:2446-55

More Related