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Skeletal Response to Weightlessness in the Female Murine Tibia

Skeletal Response to Weightlessness in the Female Murine Tibia. Amy Brazin, NASA Apprentice Maria Squire, Ph.D. Candidate Stefan Judex, Ph.D. August 20, 2004. Metaphyseal BV/TV is 30% lower in disuse mice

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Skeletal Response to Weightlessness in the Female Murine Tibia

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  1. Skeletal Response to Weightlessness in the Female Murine Tibia Amy Brazin, NASA Apprentice Maria Squire, Ph.D. Candidate Stefan Judex, Ph.D. August 20, 2004

  2. Metaphyseal BV/TV is 30% lower in disuse mice Metaphyseal Ct.Ar is lower by 15%as a result of a decrease in Ps.Ar and increase in Ec.Ar Yet, diaphyseal Ct.Ar was only minimally affected (3%)due to an insignificant increase in both Ps.Ar and Ec.Ar Example: Effects of Disuse are Site-Specific

  3. If I had more time, I would…. • Analysis male F1 mice for similar effects in the tibia • Examine the osteoclast, osteoblast, and osteoid growth and population density in specific sites • Research other causes of bone loss such as hormonal secretions

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