Why Nutracuedicals

1. Why Nutracuedicals Stephanie Ng Supervising Coordinator NutraMetrix Consultant TLS Trainer Certified Trainer

2. Inadequate Intakes from Food Percentage of Americans with Inadequate Intakes from Food Based on Estimated Average Requirements (EAR) – from NHANES 2001-2002 SOURCE: What We Eat In America, NHANES 2001-2002. EAR is daily intake to meet the requirement of 50% of the healthy individuals in a particular group.

3. Recommended Consumed consumption by 9-13 y/o females Data from Food & Nutrition Service, USDA Dietary Guidelines for Americans 2005Recommendations vs Consumption

4. The latest research shows… • Changing lifestyle can create changes in our genes in only three months—turning on hundreds of genes thatpreventdisease and turning off genes associated with breast cancer and prostate cancer as well as genes that cause heart disease, oxidative stress, and inflammation” • Lifestyle changes can also increase telomerase, the enzyme that lengthens telomeres, the ends of our chromosomes that control how long we live INTEGRATIVE CARE: A PATHWAY TO A HEALTHIER NATION • Senate Committee on Health, Education, Labor and Pensions 2009

5. Who is Recommending Supplements? • Dietary Guidelines for Americans 2010: The Dietary Guidelines recognize that “dietary supplements or fortification of certain foods may be advantageous in specific situations to increase the intake of a specific vitamin or mineral.” • American Heart Association (Folate, Omega-3’s) • American Medical Association (Multivitamin 1-2/day) • Tufts - Nutrition Research Center • Harvard School of Public Health (Multivitamin + Vit D)

6. Dietary Supplement Usage • NNFA data suggest more than 242 million Americans take supplements: • - 70% claim to feel better • - 67% take them to prevent illness • - 60% take vitamins to help them when sick • - 49% use them because their doctor suggested them • Many sources estimate 65% Americans take supplements • Americans get information about supplements from: books and magazines (30%), physicians (22%), health food store staff (19%), friends (18%), and pharmacists (16%) • 53% of pharmacists use dietary supplements personally but fewer recommend them to patients (personal use correlated with 2-fold increase in likelihood that the pharmacist would recommend supplements) from: http://www.naturalproductsassoc.org/

7. Vitamin and Mineral Supplement Use among US Medical Students: A Longitudinal Study Spencer et al, J. American Dietetic Assoc. (2006)106:1975-1983. • Half students surveyed use multivitamins (n=2,316 students; 16 schools; 80% response rate) • 19% of students used Ca supplements • Supplement usage was higher: if exercised regularly, had children, were underweight, or were female • Healthy Doc-Healthy Patient study suggests healthier med students continue practices as physicians and create a healthier patient population

8. Reasons for Supplementation • Poor dietary choices • Decreased nutrient density in foods (fast growing crops, agricultural practices, premature harvest, etc.) • Poor nutritional status due to stressful lifestyles • Over-fed but under-nourished (obesity) • Documented ability to compensate genetic vulnerabilities with nutritional intervention • Poor nutrient absorption (decreased bioavailability, GI disease, or by-pass)

9. Why HP Should Support Nutraceutical Supplementation? Poor dietary choices Poor quality of “fresh fruits” and other produce (due to soil depletion, modern agricultural methods) Chronic stressful lifestyle →→ Results in poor nutritional status “over fed but undernourished” Ability to compensate genetic vulnerabilities with nutritional supplementation

10. Science-Based vs. “Junk Science” Stephanie Ng Supervising Coordinator NutraMetrix Consultant TLS Trainer Certified Trainer

11. Science-Based vs. “Junk Science” • Common sense discussion • Nutritional supplement industry is approaching a trillion dollars annually • High percentage of your patients take supplements

12. Science-Based vs. “Junk Science” • A large percentage of Americans are purchasing supplements each and every day • Common choices are • Calcium supplements • Multivitamins • Omega or Fish Oils

13. Science-Based vs. “Junk Science” • Patients have already been “sold” on supplementation and are willingly spending money on products often WITHOUT their health professionals recommendation or knowledge

14. Science-Based vs. “Junk Science” • Consumers are confused. • They want help with decisions on measures to optimize their health • They expect this information from their health professional ?

15. Science-Based vs. “Junk Science” • WHAT are your patients buying? • Who is giving them advice? • Store clerks or students working part-time jobs in retail stores often do not have formal nutraceutical training, nor do they have any information on the patients past or current medical history.

16. “Other Ingredients” Science-Based vs. “Junk Science” • Many of the most popular brands have attractive labels full of nutritional ingredients, but also contain • artificial chemical dyes • artificial, chemically synthesized flavoring agents • preservatives, • disintegrating agents • "bulk fillers" such as talc or starch, hydrogenated oil, chemical coatings

18. Science-Based vs. “Junk Science” • Most commercial tablet and capsule vitamins have poor absorption rates. (“bedpan bullets”) • Even the vitamin pills that do breakdown, are exposed to 45 minutes to 4 hours of exposure to stomach acids and enzymes before they ever reach the absorption site in the intestines.

20. What should HPs consider when choosing nutritional supplementation for their patients/clients? Efficient delivery system (good bioavailability) Comprehensive and synergistic formulations Taste and palatability Scientifically based High standards for quality control (QC) Good label information including warnings and contraindications

21. Bioavailability • What is bioavailability? • Reflects the amount of nutrient your body can absorb and utilize • Dependent on the delivery system and the formulation (e.g. amino acid chelate) • Delivery system is very important: • Isotonic > capsules > pills/tablets • Binders and fillers can decrease absorption • Capsules and pills often rely on stomach acid

22. Our Unique Isotonic Delivery System • “iso” = same and “tonic = pressure or tone same fluid pressure or tone of the body (i.e. tears, plasma, lymph and other body fluids) • Isotonicity allows fluids to move easily through small intestinal membranes • Formulated with proper balance of fructose, d-glucose, citric acid and potassium bicarbonate to assure continued isotonicity (no fillers or binders)

24. How Fast is “Fast”? Tablet partially dissolves and then propelled into intestine. M.R. Cesarone, et al. Phytother. Res. 2009

25. The Isotonic advantage…. • Offer advantages from a scientific, nutritional and marketing perspective • Who is the target audience? • Any one wanting enhanced nutrient absorption • Persons who need support for GI absorption. • People who need digestive support (i.e. elderly) • Person’s who have difficulty swallowing pills, tablets, (those who prefer to drink their supplementation) • Individual that takes the isotonic nutrition FEEL THE DIFFERENCE ! • This makes Isotonix products “Market Driven”

26. Product Broker vs. Product Manufacturer • As a product broker, nutraMetrix® enters into exclusive agreements with multiple suppliers, ensuring the highest quality products in varying categories • Does not rely on the sale of one manufacturer’s products • Can move with the marketplace • High Standard of Quality Control

27. Comprehensive and Synergistic Formulations • Based on current research • Example- Heart Health™ Omega III provides 3g of EPA and DHA per day when taken as directed (two soft gels, twice daily). It also contains natural Vitamin E to prevent rancidity. Other products on the market contain much less of the active ingredients than what current literature supports as adequate intake • Many nutrients require cofactors and other nutrients that are not always present in competitors formulations

28. QC Process at Market America • Specifications set for raw materials and finished products. • Raw materials are sourced with Certificates of Analysis. • Products are manufactured using Standard Operating Procedures (SOP’s) under FDA’s Good Manufacturing Practice (GMP) Standards. • Products are inspected at our warehouse for damage, label accuracy, appearance, taste, and odor prior to release. • Product is quarantined, if it fails to pass inspection. • Products are assayed by independent labs for isotonic capability, microbial contamination & potency. • Manufacturing facilities are audited on a regular basis for compliance.

30. Products • Isotonix® Multivitamins • Isotonix® Bs • Isotonix®OPC-3 • Isotonix®Calcium • Omega 3 • PRIME® Joint • Glucosatrin®

31. nutraMetrixIsotonix® Multivitamin(available with and without iron) Primary Benefits Of nutraMetrix® Isotonix® Multivitamin*:  • Supports a healthy immune system • Contains 100 percent or more of the recommended daily value of essential vitamins and minerals • Promotes the conversion of food into energy • Supports a healthy cardiovascular system • Supports strong bones • Promotes skin health • May promote mental clarity • Helps maintain normal blood pressure • Supports a healthy thyroid • Promotes normal healing • Helps maintain normal metabolic functioning • Supplements deficiencies in diet

32. What makes this product Unique? • Isotnoic Delivery system. 95% absorption • Providing 100 percent or more of the Daily Value of 15 essential vitamins and minerals.

33. nutraMetrixIsotonixOPC-3® Primary Benefits of nutraMetrixIsotonix OPC-3®*: • Combats free radicals • Demonstrates anti-inflammatory activity • Helps maintain healthy cholesterol levels • Helps maintain healthy circulation by strengthening capillaries, arteries and veins • Helps maintain joint flexibility • Helps promote cardiovascular health • Helps reduce mild menstrual cramping and abdominal pain • Helps support visual health/visual acuity • Potent free radical scavenger • Promotes healthy blood vessel dilation • Promotes healthy nitric oxide levels • Supports a healthy complexion

34. What makes this product Unique? • Isotonic Delivery system. 95% absorption • Studies have shown OPCs to be up to 20 times more powerful than vitamin C and 50 times more powerful than vitamin E in neutralizing free radicals. nutraMetrixIsotonix OPC-3 contains the only isotonic form of Pycnogenol® in the world. Pycnogenol is a natural plant extract from the bark of the French maritime pine tree and the most clinically researched and potent bioflavonoid.* • We are the world sole provider of IsotonixPycnogenol®

35. Frequently Asked Questions • What are antioxidants and what do they do? • Antioxidants are molecules that inhibit chemical reactions in the body that can cause free radicals. Free radicals are unstable molecules or compounds. Specifically, antioxidants can stabilize free radicals and prevent other molecules from turning into unstable free radicals.* • Is this product safe? • Yes. OPCs are among the most valuable constituents of a healthy human diet. OPCs have been researched and used for over 30 years throughout Europe. Extensive safety studies and lab testing reveal no evidence of human toxicity. nutraMetrixIsotonix OPC-3 contains pure OPCs and additional bioflavonoids. Balanced quantities of potassium and fructose/glucose are added to allow nutraMetrixIsotonix OPC-3 to become isotonic when mixed with water as directed on the label. nutraMetrixIsotonix OPC-3 is free of harmful chemicals, preservatives and alcohol. It should be taken as directed on the label. • What is the advantage of taking this product regularly? • Taking nutraMetrixIsotonix OPC-3 daily enables the body to sustain a consistent antioxidant defense, promote cardiovascular health and many more benefi ts.* • How do I take nutraMetrixIsotonix OPC-3? • Pour 1 level, white bottle capful of powder into the overcap. Add water to the line on the overcap (2 fl . oz./60 mL) and stir. As a dietary supplement, take once daily or as directed by your healthcare provider. Take 2 capfuls per 150 pounds of body weight daily for the fi rst • 7-10 days, and take 1 capful daily thereafter as a maintenance program. Maximum absorption occurs when taken on an empty stomach. This product is isotonic only if the specified amounts of powder and water are used.

36. nutraMetrixIsotonix® Multivitamin(available with and without iron) Primary Benefits Of nutraMetrix® Isotonix® Multivitamin*:  • Supports a healthy immune system • Contains 100 percent or more of the recommended daily value of essential vitamins and minerals • Promotes the conversion of food into energy • Supports a healthy cardiovascular system • Supports strong bones • Promotes skin health • May promote mental clarity • Helps maintain normal blood pressure • Supports a healthy thyroid • Promotes normal healing • Helps maintain normal metabolic functioning • Supplements deficiencies in diet

37. nutraMetrix® Heart HealthEssential Omega III Fish Oil with Vitamin E™ Primary Benefits of nutraMetrix® Heart Health™ Essential Omega III Fish Oil *: • Helps maintain normal cholesterol levels • Helps maintain healthy blood pressure levels • Helps maintain normal blood flow • Helps maintain normal triglyceride levels in the blood • Promotes overall cardiovascular health • Helps maintain healthy levels of C-reactive protein • Promotes a healthy complexion • Helps enhance mood • Promotes healthy lubrication of the eye • Promotes normal tear production and volume • Helps promote healthy blood flow to the eye • May help to retain low-light visual acuity • Supports joint health • Supports relief from temporary inflammation associated with the normal aging process and daily activity

38. What Makes This Product Unique? • nutraMetrixHeart Health Essential Omega III Fish Oil with Vitamin E is a superior product due to a number of factors. nutraMetrixHeart Health Essential Omega III Fish Oil with Vitamin E provides a high quality, high purity product with significant percentages of health-promoting EPA and DHA. The best fish are used to produce a clean and safe product that is rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). It also contains 3000 mg of fi sh oil, where most other commercial products contain a third of the total fi sh oil contained in nutraMetrix Heart Health Essential Omega III. • nutraMetrixHeart Health Essential Omega III Fish Oil with Vitamin E comes from sardines and anchovies harvested off the coast of Peru. Not only do anchovies and sardines have a high Omega 3, EPA and DHA content, they have a short lifecycle. This makes them an ideal source of fish oil because they are less prone to accumulating environmental toxins that can be found in larger, longer-lived fish that are used by some competitive products. Anchovies and sardines are also lower in the food chain and accumulate fewer fat-soluble toxins. Contaminants are generally low in sardines and anchovies even before they go through an intense purification process. • The fish oil used in nutraMetrix Heart Health Essential Omega III Fish Oil with Vitamin E is tested twice, once by the manufacturer and then by an independent testing company for mercury, lead, PCB, and other heavy metals. We only use fish oil that meets or exceeds • standards set by Canada (CFIA), the European Union (EU) and the United States (CRN).*

39. Frequently Asked Questions • Is the fish oil used in nutraMetrix Heart Health Essential Omega III tested for heavy metals? • Yes. The fish oil used in nutraMetrix Heart Health Essential Omega III Fish Oil with Vitamin E is laboratory tested for PCBs, dioxin and heavy metals. We only use fish oil that meets or exceeds standards set by Canada (CFIA), the European Union (EU) and the United States(CRN). • Is this product vegetarian? • No. This product contains gelatin and fish oils. • What is meant by “50 percent purity”? • The 50 percent purity refers to the concentration of the essential fatty acids EPA and DHA. The remaining 50 percent are assorted fatty acids contained within the fi sh oils. • What lifestyle recommendations promote heart health? • Simple, everyday choices you can make to help maintain proper heart health include: • Do not smoke, and avoid exposure to smoke • Maintain a healthy height-to-weight ratio • Eat a diet rich in colorful fruits, vegetables and whole grains • Limit your consumption of total, saturated and trans fats • Exercise regularly and include cardiovascular and resistance training • Work with your healthcare provider to monitor cholesterol, blood pressure, and homocysteine and C-reactive protein levels. Start a complete nutritional supplementation program designed to help promote and maintain proper cardiovascular health • How do I take nutraMetrix Heart Health Essential Omega III Fish Oil with Vitamin E? • Take 2 softgels once daily with 8 fl . oz./240 mL of water or as directed by your healthcare provider. Maximum absorption occurs when taken with a meal.

40. nutraMetrixIsotonix® Calcium Complete Primary Benefits of nutraMetrix® Isotonix® Calcium Complete: • Supports skeletal health • Adequate calcium and vitamin D throughout life, as part of a well-balanced diet, may reduce the risk of osteoporosis • Adequate calcium and vitamin D as part of a healthful diet, along with physical activity, may reduce the risk of osteoporosis in later life • Supports cardiovascular health • Plays a critical role in the normal contraction of skeletal and heart muscles • Supports normal muscle use and performance • Supports healthy teeth and gums • Helps to maintain healthy immune functions and general wellbeing • Helps maintain healthy cholesterol levels • Supports proper nerve conduction • Promotes normal regulation of hormones and enzyme production • Promotes normal hormone secretion • Promotes normal enzyme and hormone regulation • Helps to ease the discomfort of PMS • Promotes normal blood clotting • Supports healthy blood sugar levels • Supports healthy body weight • Supports healthy pregnancy and fetal development

41. What Makes This Product Unique? • Isotonic Delivery system • Provides the body with an optimal blend of calcium, vitamin D3, magnesium, vitamin C and boron in an efficient isotonic solution that is readily absorbed by the body. • The efficiency of absorption is also affected by the digestive system. All substances that are used in the stomach go through a degradation process (breakdown) before they can be passed through the opening from the stomach to the small intestine to allow absorption. The digestive process can cause substances to lose some nutritive value, and this whole process takes time! • nutraMetrixIsotonix Calcium Complete paves the way for powerful results since it is in an isotonic form rather than a tablet. Calcium in tablet form is difficult for your body to absorb. People may fail to absorb tablet calcium supplements because the calcium supplement is not blended with vitamin D and magnesium; these are necessary to aid in the absorption and use of calcium. • Even if the calcium tablet is blended correctly, it may be difficult for the body to utilize or break down the calcium. One explanation may be that many calcium brands use calcium from eggshell or oyster shell. These may not be well absorbed by the body. Another reason calcium may not be absorbed from a tablet is because of DCP, which is a binding agent used to hold the tablet together. DCP does not break down in the body. • In addition to binders, some calcium supplements may have additives such as chlorine and other chemicals. Even assuming no binders are used in the calcium tablet, the body must still break down a hard-pressed tablet into a usable form. If the tablet cannot be broken down sufficiently in the stomach, then the calcium will not be absorbed. If you can't break down the calcium, your body is robbed of the calcium needed to support bodily functions. • Ordinary calcium tablets require stomach acid to dissolve their compounds, but nutraMetrixIsotonix Calcium Complete has no need of stomach acid to be utilized. It delivers an efficient calcium solution that is more readily absorbed by the intestine. Its natural lemon-lime flavor is preferable to the chalky taste of typical chewable calcium wafers or tablets. • Many calcium supplements exist in the marketplace, but only nutraMetrixIsotonix Calcium Complete delivers a potent package of calcium and complementary nutrients through an isotonic system of delivery. This translates into a lower cost overall when compared to calcium supplements in pill form by making more of the active ingredients available to the body. Don't be misled by ingredient amounts. What really counts is the amount of active ingredients that your body can ultimately use.

42. Frequently Asked Questions Why should I take calcium? • Everyone needs calcium. Very few people ingest enough calcium in their daily diet. Besides being helpful in supporting and maintaining bone integrity, calcium serves a dynamic role as a mineral. It's very important in supporting the activity of many bodily enzymes and maintaining proper fluid balance. nutraMetrixIsotonix Calcium Complete also promotes the normal contraction of skeletal and muscle.According to the Surgeon General, taking a calcium supplement daily is key to preventing and treating calcium deficiency and to helping reduce the risk of osteoporosis. Currently, osteoporosis affects over one-third of postmenopausal women in this country. Recent clinical statistics also indicate that aging men are also likely to become susceptible to osteoporosis.*   How much calcium should I take?The National Academy of Sciences has established guidelines for calcium that are 25-50 percent higher than previous recommendations. For ages 20 to 50, calcium consumption is recommended to be at least 1,000 mg daily; for adults over age 51, the recommendation is 1,200 mg daily. The most common supplemental amount for adults is 800 to 1,000 mg per day. Some physicians recommend 1,000 milligrams of supplement calcium daily for postmenopausal women taking estrogen replacement therapy (ERT) and 1,500 milligrams daily for postmenopausal women not taking ERT. Everyone should be getting appropriate calcium intake. The Food and Nutrition Board of the Institute of Medicine of the U.S. National Academy of Sciences has recommended the following adequate intakes (AI) for calcium. Examine the table provided in order to determine appropriate calcium intake requirements:Infants (from breast milk or formula) (AI)0-6 months 200 mg/day7-12 months 270 mg/dayChildren (from their regular dietary intake)  1-3 years 500 mg/day4-8 years 800 mg/dayBoys & Girls  9-13 years  1,300 mg/day14-18 years  1,300 mg/day31-50 years  1,000 mg/day*Source: National Academy of Sciences Men  19-30 years  1,000 mg/day31-50 years  1,000 mg/day51-70 years  1,200 mg/day>70 years  1,200 mg/dayWomen  19-30 years  1,000 mg/day31-50 years  1,000 mg/day51-70 years  1,200 mg/day>70 years  1,200 mg/day Pregnancy  14-18 years  1,300 mg/day19-30 years  1,000 mg/day31-50 years  1,000 mg/dayLactation  14-18 years  1,300 mg/day19-30 years  1,000 mg/day31-50 years  1,000 mg/day

43. Frequently Asked Questions I'm not an elderly woman. Why should I take a calcium supplement?Calcium plays a huge role in regulating many major bodily processes with implications that extend far beyond the age factor. Other than elderly women who may be susceptible to bone loss, younger women, pregnant and lactating women, growing children and men should take a calcium supplement. Younger women need more calcium to build up the strength of their bones. Pregnant and lactating women need extra calcium, at least 1200 mg /day to foster the healthy growth of new cells and of breast milk. Growing children need extra calcium, sometimes two to four times as much as an adult to assist with new bone development and proper growth. Finally, those with poor cardiovascular health have been found to have low levels of calcium intake. Studies have confirmed that calcium supplementation supports heart health.* I've heard calcium is great for PMS? How so?PMS is an undesirable influence on physical and psychological peace of mind. Recent studies have found that over 70 percent of relationships are affected in some way by PMS. So PMS impacts nearly everyone, including men! • Supplementation with calcium can reduce PMS symptoms. In a study conducted by the US Department of Agriculture's Human Nutrition Research Center, it was found that women on a high calcium diet had decreased irritability, cramping and bloating associated with PMS. Ovarian hormones affect calcium, magnesium and vitamin D metabolism. Estrogen regulates calcium metabolism, intestinal calcium absorption and parathyroid gene expression and secretion, triggering fluctuations across the menstrual cycle. As a woman menstruates, her hormones are "all over the place". Clinical trials in women with PMS have found that calcium supplementation helps reduce mood and somatic symptoms associated with PMS.* What is the suggested age to begin taking nutraMetrixIsotonix Calcium Complete? • nutraMetrixIsotonix Calcium Complete is recommended for all adults age 18 or older. • If we only absorb 300 to 400 mg of calcium at a time, why does one capful contain 750 mg?There are 750 mg of calcium in two capfuls of nutraMetrixIsotonix Calcium Complete. Therefore one capful equals 375 mg of calcium.

44. Frequently Asked Questions Why is nutraMetrixIsotonix Calcium Complete better than other calcium products?It is better because of the Isotonix delivery system. The secret of the isotonic process is probably now becoming clear. When an isotonic substance enters the body, it will be absorbed into the bloodstream rapidly. With isotonic fluids, little nutritive value is lost, making the absorption of nutrients highly efficient. There is nothing artificial about it. An isotonic fluid is nature's own nutrient delivery system. Why is there a sandy residue left in the cup after mixing with water?Everyone's water is different; some tap water has a higher concentration of minerals and the pH level of water differs depending on geographic location and the quality of the tap water, which can lead to inconsistencies with the saturation point of a solution. To ensure that our solutions reach the point of saturation, regardless of the pH or mineral levels in water, we have maximized the formulation amounts so that every serving of nutraMetrixIsotonix Calcium Complete contains the correct amount of calcium. The residue left in the cup is due to over-saturation, which is common in tap water with a higher pH level or a higher mineral content. What form of calcium should I take?The best form of calcium is calcium carbonate, which is utilized by the body more efficiently due to the fact that it increases the absorbability. Additionally, calcium is more readily absorbed by the body when in combination with magnesium, manganese, vitamin C, vitamin B2, boron and potassium. nutraMetrixIsotonix Calcium Complete is formulated with calcium carbonate, and the additional vitamins and minerals needed in an isotonic form which allows for maximum utilization and absorption of calcium by the body, and reduces the nutritive loss found in many calcium tablets or capsules

45. nutraMetrixIsotonix® Activated B-Complex Primary Benefits of nutraMetrix®Isotonix® Activated B-Complex*: • Contains activated forms of select B vitamins to ensure optimal utilization by the body • Helps decrease stress and improve mood • Helps maintain healthy levels of serotonin • Increases energy • Meets need for B-vitamins in a vegetarian diet • Promotes cardiovascular health • Promotes healthy levels of homocysteine • Promotes normal cognitive performance

46. What Makes This Product Unique? • nutraMetrixIsotonix Activated B-Complex delivers metabolically active forms of several vitamins and minerals in isotonic form, ensuring that your body receives and uses vital nutrients quickly and efficiently. B-vitamins can provide you with a number of health benefits, however, some B-vitamins, such as B6, B12 and folic acid, must undergo chemical changes before they can be utilized by the body. Furthermore, different factors, such as age and physical condition, may affect the body’s ability to activate vitamins on its own. If the non-active forms are used, the body is forced to work harder to gain the full benefit of the vitamin. These steps are eliminated when the forms used are already in their active states.By utilizing both the activated form of these vitamins, as well as the superior Isotonix delivery system, nutraMetrixIsotonix Activated B-Complex supports your body’s absorption and immediate use of beneficial ingredients.* • nutraMetrixIsotonix dietary supplements are delivered in an isotonic solution.

47. Frequently Asked Questions about nutraMetrix® Isotonix® Activated B-Complex:   What does “Activated” refer to in nutraMetrixIsotonix Activated B-Complex? Activated refers to the active forms of vitamins B6, B12 and folic acid. Using forms other than these activated forms requires that the vitamins be enzymatically activated prior to utilization by the body. Not only does this take time and energy within the body, there are circumstances in which this reaction is either slowed or inhibited. What is the source of the vitamin B12 in our nutraMetrixIsotonix Activated B-Complex?The Vitamin B-12 is synthesized under controlled culture conditions by specific “friendly” bacteria. B12 in our diet can come from eggs, meats, peanuts, and fermented soy or by taking a supplement. Vegetarians are recommended to take a B vitamin dietary supplement due to their lack of meat intake. Why are B-vitamins so important in the aging process? B vitamins are important and necessary for numerous metabolic processes within the body.  As people age, the ability to absorb vitamins decreases and reduced levels of these vitamins have been associated with impaired cognitive performance. The US RDA’s Human Nutrition Center on Aging claims vitamin B12 is the most important nutrient negatively affected by aging. Since vitamin B12 plays a critical role in promoting normal energy production and nervous system function, aging individuals need to make sure they are getting enough vitamin B12 on a daily basis.*

48. Frequently Asked Questions about nutraMetrix® Isotonix® Activated B-Complex:   What does “Activated” refer to in nutraMetrixIsotonix Activated B-Complex? Activated refers to the active forms of vitamins B6, B12 and folic acid. Using forms other than these activated forms requires that the vitamins be enzymatically activated prior to utilization by the body. Not only does this take time and energy within the body, there are circumstances in which this reaction is either slowed or inhibited. What is the source of the vitamin B12 in our nutraMetrixIsotonix Activated B-Complex?The Vitamin B-12 is synthesized under controlled culture conditions by specific “friendly” bacteria. B12 in our diet can come from eggs, meats, peanuts, and fermented soy or by taking a supplement. Vegetarians are recommended to take a B vitamin dietary supplement due to their lack of meat intake. Why are B-vitamins so important in the aging process? B vitamins are important and necessary for numerous metabolic processes within the body.  As people age, the ability to absorb vitamins decreases and reduced levels of these vitamins have been associated with impaired cognitive performance. The US RDA’s Human Nutrition Center on Aging claims vitamin B12 is the most important nutrient negatively affected by aging. Since vitamin B12 plays a critical role in promoting normal energy production and nervous system function, aging individuals need to make sure they are getting enough vitamin B12 on a daily basis.*

49. nutraMetrixGlucosatrin® with Vitamin D3 Primary Benefits of nutraMetrixGlucosatrin® Bone and Joint Formula*: • Helps regulate the immune response to stimuli • Promotes skeletal health • Helps maintain strong bones • Promotes normal movement and flexibility of joints • Promotes the retention and normal regeneration of cartilage • Helps maintain joint comfort • Promotes joint health and flexibility as you age • Supports normal, healthy 5-LOX and COX-2 levels

50. What Makes nutraMetrixGlucosatrin® Bone and JointFormula Unique? • nutraMetrixGlucosatrin with Vitamin D3 is a glucosamine-based formula that promotes overall joint and bone health. Glucosamine is anaminomonosaccharide that is concentrated in joint cartilage and bonded to form amino polysaccharides. Glucosamine supports healthy joint function and promotes the normal production of synovial fluid, which lubricates your joints and regenerates cartilage. • nutraMetrixGlucosatrinwith Vitamin D3 combines glucosamine with other natural, joint-healthy ingredients to achieve a formula that promotes joint flexibility, supports normal cartilage regeneration and retention and helps maintain normal joint movement during the aging process.* • nutraMetrixGlucosatrin with Vitamin D3 promotes joint comfort and helps maintain proper function in healthy joints.*