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PROGNOSIS dan PREDIKTIF pada KANKER

PROGNOSIS dan PREDIKTIF pada KANKER. d r. Daan Khambri, SpB(K)Onk, M.Kes Subbagian Bedah Onkologi, Bagian Bedah FK-UNAND / RS UP Dr.M.Djamil. Dr. H. Daan Khambri, SpB (K) Onk, M.Kes Dokter Spesialis Bedah Konsultan Bedah Onkologi / HNB (Bedah Tumor) Lahir di DUMAI, tanggal 6 Mei 1967.

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PROGNOSIS dan PREDIKTIF pada KANKER

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  1. PROGNOSIS dan PREDIKTIF pada KANKER dr. Daan Khambri, SpB(K)Onk, M.Kes Subbagian Bedah Onkologi, Bagian Bedah FK-UNAND / RSUP Dr.M.Djamil

  2. Dr. H. Daan Khambri, SpB (K) Onk, M.Kes Dokter Spesialis Bedah Konsultan Bedah Onkologi / HNB (Bedah Tumor) Lahir di DUMAI, tanggal 6 Mei 1967 Pendidikan : SD, SMP, SMA di DUMAI s/d Th 1985. S1 – Dokter Umum (FK-UNAND Padang, 1991). Sp1 – Spesialis Bedah (FK-UNAND Padang, 2003). S2 – Magister Kesehatan (FK-UNPAD Bandung, 2007). Sp2 – Konsultan Bedah Onkologi (FK-UNPAD Bandung, 2007). Pekerjaan :- Staf Subbagian Bedah Onkologi, Bagian Bedah FK-UNAND / RSUP Dr.M.Djamil Organisasi Profesi :IDI, IKABI, PABI, PERABOI, POI Riwayat Pekerjaan : 1992-95 PUSKESMAS Rantau Pandan Bungo Tebo JAMBI. 1995-96 PUSKESMAS SALIMPAUNG Tanah Datar SUMBAR. 2003-04 RSUD SUNGAI DAREH Kab. DHARMASRAYA. 2007- RSUP Dr.M.Djamil / FK-UNAND Padang. Padang, 2011 Curiculum Vitae Daan K, Blok 2.1 Prognosis & Prediktif Kanker

  3. BUKU RUJUKAN • Bradley KT. CAP Cancer Committee. Prognostic and Predictive Factors in Breast Cancer. Newspath. Sept 1. 2007. • UICC, International Union Against Cancer. Prognostic Factors in Cancer. 3rd Ed. 2006. • Gede Sukardja. Onkologi Klinik. Edisi 2. 2000. Daan K, Blok 2.1 Prognosis & Prediktif Kanker

  4. CARA TERAPI KANKER • SURGERY • RADIATION THERAPY • CHEMOTHERAPY • HORMONAL THERAPY • MOLECULAR-TARGET THERAPY Daan K, Blok 2.1 Prognosis & Prediktif Kanker

  5. Combination Therapy : MULTIMODALITAS Daan K, Blok 2.1 Prognosis & Prediktif Kanker

  6. prognostic factor Definisi : • a measurablevariable that correlates with the natural history of the disease Daan K, Blok 2.1 Prognosis & Prediktif Kanker

  7. prognostic factor • Faktor yang dapat dipakai untuk meramalkan perjalanan penyakit kanker Daan K, Blok 2.1 Prognosis & Prediktif Kanker

  8. PROGNOSTIC FACTOR • PENDERITA • TUMOR • TERAPI Daan K, Blok 2.1 Prognosis & Prediktif Kanker

  9. PENDERITA • Umur • Kelamin • Suku Bangsa • Genetik • Status Umum • Status Penampilan • Imunitas • Co-Morbiditas • Gizi • Sosial Ekonomi Daan K, Blok 2.1 Prognosis & Prediktif Kanker

  10. TUMOR • Topografi/Jenis Kanker • Morfologi/Patologi • Derajat Keganasan • Stadium • Luas Ekstensi Tumor • Lokasi dan luas meta • Reseptor Hormon • Petanda Tumor • Multisentris • Radio/Khemo sensitivitas Daan K, Blok 2.1 Prognosis & Prediktif Kanker

  11. TERAPI • Jenis terapi • Lengkap / tidak • Radikalitas operasi • Respon terhadap terapi • Fasilitas • Keahlian Dokter • Kerjasama tim multidisiplin Daan K, Blok 2.1 Prognosis & Prediktif Kanker

  12. Predictive Factor Definisi : • is associated with response to a given therapy. Daan K, Blok 2.1 Prognosis & Prediktif Kanker

  13. Predictive Factor • Faktor prediksi adalah sesuatu yang berpengaruh secara spesifik terhadap jenis pengobatan tertentu Daan K, Blok 2.1 Prognosis & Prediktif Kanker

  14. Prognostic Factors inBreast Cancer • Age • Tumor size • Axillary node status • Histological tumor type • Pathologic grade • Hormonal receptor • HER-2/neu Daan K, Blok 2.1 Prognosis & Prediktif Kanker

  15. BREAST CANCERStage I T1 N0 M0 T1a: T  0.5 cm T1b: 0.5 cm < T  1 cm T1c: 1 cm < T  2 cm T1 T  2 cm N0 = no regional lymph node metastasisM0 = no distant metastasis Daan K, Blok 2.1 Prognosis & Prediktif Kanker

  16. BREAST CANCERStage IV Any T any N M1 M1 = distant metastasis (including metastases to ipsilateral supraclavicular, cervical, or contralateral internal mammary lymph nodes) Daan K, Blok 2.1 Prognosis & Prediktif Kanker

  17. RESEPTOR HORMON • Estrogen reseptor (ER) • Progesteron Reseptor (PR) • Epidermoid growth factor reseptor (EGFR) / Her2 Daan K, Blok 2.1 Prognosis & Prediktif Kanker

  18. JENIS RESEPTOR • Reseptor hormon positif • Reseptor hormon negatif Reseptor hormon menentukan sensitivitas kanker terhadap hormon Daan K, Blok 2.1 Prognosis & Prediktif Kanker

  19. Daan K, Blok 2.1 Prognosis & Prediktif Kanker

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