1 / 35

Supplemental Data

Comprehensive analysis of tumor genetic data reveals allele frequency, copy number changes, and mutation concordance across samples. Detailed plots and subclone identification provided.

casea
Download Presentation

Supplemental Data

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Supplemental Data

  2. Supplement 1: Allele Frequency R2, Copy Number R2, and Mutation Percent Concordance for all samples in each tumor

  3. Supplemental Data 2 • Allele Frequency Plots for all tumors

  4. Patient 1 Ca1 MATH = 22 Ca2 MATH = 20

  5. Patient 4 Ca1 MATH = 7 Ca2 MATH = 9

  6. Patient 11 Ca1 MATH = 11 Ca2 MATH = 11 Ca3 MATH = 11

  7. Patient 20 Ca1 MATH = 42 Ca2 MATH = 40 Ca3 MATH = 40

  8. Patient 204 Ca1 MATH = 22 Ca2 MATH = 16

  9. Patient NP1 Ca1 MATH = 24 Ca2 MATH = 14 Ca3 MATH = 19

  10. Supplemental Data 3 • Copy Number Changes in all samples.

  11. TuScan Ploidy: 4 TuScan %aberrant: 55%

  12. TuScan Ploidy: 4 TuScan %aberrant: 40%

  13. TuScan Ploidy: NA TuScan %aberrant: NA 57%

  14. TuScan Ploidy: 2 TuScan %aberrant: 70%

  15. TuScan Ploidy: 2 TuScan %aberrant: 65%

  16. TuScan Ploidy: 2 TuScan %aberrant: 65%

  17. TuScan Ploidy: NA TuScan %aberrant: NA 45%

  18. TuScan Ploidy: 2 TuScan %aberrant: 55% 70%

  19. TuScan Ploidy: 4 TuScan %aberrant: 80% 90%

  20. TuScan Ploidy: NA TuScan %aberrant: NA 50%

  21. TuScan Ploidy: NA TuScan %aberrant: NA 40%

  22. TuScan Ploidy: NA TuScan %aberrant: NA 30%

  23. TuScan Ploidy: NA TuScan %aberrant: NA 45%

  24. TuScan Ploidy: 2 TuScan %aberrant: 50% 66%

  25. TuScan Ploidy: NA TuScan %aberrant: NA 45%

  26. Supplemental Data 4 • SciClone plots

  27. P1: Three individual subclones were identified in the 2 copy number state and are all in both spatially distinct samples.

  28. P4: Three individual subclones were identified in the 2 copy number state and are all in both spatially distinct samples.

  29. P11: Six individual subcloneswere identified in the 2 copy number state. Subclones 1 and 2 are shared between samples but subclones 3 and 4 are just in sample 1, subclone 5 is just in sample 2 and subclone 6 is just in sample 3.

  30. P20: Eight subclones were identified in the 2 copy number state and they were shared between samples.

  31. P204: Two subclones were identified in the 2 copy number state and they were shared between samples but more prevelent in Sample 1 than 2.

  32. NP1: Three subclones were identified in the 2 copy number state and all are shared between the different tumor samples.

More Related