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C-myc

C-myc. Presented by Tavia Clark. c-Myc: The Quintessential Oncogene. Transcription factor involved in: Cell growth Cell proliferation Repression of gene transcription Apoptosis Angiogenesis. *Symbols: +, effect tested for and seen; −, effect tested for and not seen;

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C-myc

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  1. C-myc Presented by Tavia Clark

  2. c-Myc: The Quintessential Oncogene • Transcription factor involved in: • Cell growth • Cell proliferation • Repression of gene transcription • Apoptosis • Angiogenesis

  3. *Symbols: +, effect tested for and seen; −, effect tested for and not seen; ?, not tested (or not reported)

  4. Links • http://arjournals.annualreviews.org/doi/full/10.1146/annurev.physiol.60.1.575?cookieSet=1 • http://www.myccancergene.org/index.asp • http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1550296 • http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T23-44Y0Y3F-1&_user=130907&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000004198&_version=1&_urlVersion=0&_userid=130907&md5=aa23778ee7ca3420a6b4cb277d165126 • http://www.tumor-gene.org/cgi-bin/TGDB/tgdb_fetch_gene.cgi?gene=myc • http://www.cancerindex.org/geneweb/MYC.htm • http://news-service.stanford.edu/news/2004/october13/med-felsher-1013.html

  5. Articles • Bruno Amati, Konstantinos Alevizopoulos and Jaromir Vlach, “MYC and the Cell Cycle,” Frontiers in Bioscience, 3, d250-268 (1998) • Jonas A Nilsson and John L Cleveland, “Myc pathways provoking cell suicide and cancer,” Oncogene, 22, 9007-9021 (2003) • J Craig Cohen, et. al. “Transient in utero knockout (TIUKO) of C-MYC affects late lung and intestinal development in the mouse,” BMC Developmental Biology, 4:4 (2004) • E. Brad Thompson, “The many roles of c-Myc in apoptosis,” Annual Review of Physiology, 60, 575-600 (1998) • Werner Lutz, Javier Leon and Martin Eilers, “Contributions of Myc to tumorigenesis,” BBA Reviews on Cancer, 1602:1, 61-71 (2002) • Amy Adams “Switching off cancer gene turns cells healthy in mice,” Sanford Report, October 13, 2004 • Bruna Pucci, Margaret Kasten, and Antonio Giordano, “Cell cycle and apoptosis,” Neoplasia 2:4, 291-299 (2000)

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