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DEGRADASI ASAM AMINO

DEGRADASI ASAM AMINO. Oleh : Henzo Bernando (10507011) Rini Hapsari (10507037) Aldi Pradana (10507091) Wibawa Hendra S (10507053) Dinda Husna (10507057) Kimia ITB 2010. AGENDA. Asparagin Aspartat Valine Methionin Threonin Glutamat Glutamin Histidin Prolin Arginin.

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DEGRADASI ASAM AMINO

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  1. DEGRADASI ASAM AMINO Oleh : HenzoBernando (10507011) RiniHapsari (10507037) AldiPradana(10507091) WibawaHendraS (10507053) DindaHusna (10507057) Kimia ITB 2010

  2. AGENDA • Asparagin • Aspartat • Valine • Methionin • Threonin • Glutamat • Glutamin • Histidin • Prolin • Arginin

  3. DEGRADASI ASAM AMINO • Adalahbentukzatantarametabolikutama yang dapatdiubahmenjadiglukosaataudapatdioksidasipadadaurasamsitrat • Tiapasam amino memilikijalurdegradasi yang berbeda. • Tahappertamayaitupelepasangugusamina • Kerangkakarbon 20 asam amino pembentuk protein disalurkanmenjadi 7 molekul : piruvat, asetilKoA, asetoasetilKoA, α-ketoglutarat, suksinilKoA, fumaratdanoksaloasetat • Asam amino yang dipecahmenjadiasetil-KoAatauasetoasetil-KoAdisebutketogenik • Asam amino yang dipecahmenjadipiruvat, α-ketoglutaratdansuksinilKoA, fumaratatauoksaloasetatdisebutglukogenik

  4. Sekilastentangdegradasiasamamino

  5. DegradasiAspartat Dan Asparagin

  6. Degradasi & Defect Threonine

  7. Degradasi & Defect MethioninedanValine

  8. DegradasiGlutamatdanGlutamin

  9. DefekGlutamatdanGlutamin • efeknegatifterhadapintegritasfungsionaldariusus • menyebabkanimmunosupresi • Mengganggufungsiotak • psychiatric disorders

  10. Degradasidan Defect Histidine

  11. DegradasiProlin

  12. Proline Degradation dan Defect Proline transport defect menyebabkanMutant Phenotypes in Homozygote

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