Overview of the Harvard Catalyst Imaging program

1. Overview of the Harvard Catalyst Imaging program Randy Gollub,MD,PhD; Valerie Humblet,PhD April 28, 2009 http://catalyst.harvard.edu

2. Institutions participating in Harvard CTSC Yearly budget: $38 million (23 NIH + 15 matching) Academic Healthcare Centers • Beth Israel-Deaconess Medical Center • Brigham and Women’s Hospital • Massachusetts General Hospital • Children’s Hospital Boston Specialty Hospitals and Institutes • Dana-Farber Cancer Institute • Forsyth Dental Institute • Joslin Diabetes Center • Massachusetts Eye and Ear Infirmary • McLean Hospital • Schepens Eye Research Institute Massachusetts Institutes of Technology Harvard University • Faculty of Arts and Sciences • Harvard Business School • Harvard School of Dental Medicine • Harvard Divinity School • Graduate School of Design • Graduate School of Education • Kennedy School of Government • Harvard Law School • Harvard Medical School • Harvard School of Public Health • Harvard School of Engineering Community Healthcare Institutions • Cambridge Health Alliance • HMS Department of Ambulatory Care and Prevention at Harvard Pilgrim Healthcare 1

3. Harvard Catalyst • Programs (Selected list) • Development of Novel C/T Methodologies • Biomedical Informatics • Research Education, Career Development • Pilot studies • Community Engagement • Design and Biostatistics • Diversity and Health Disparities Research • Ethics • Linkages across the institutions • Regulatory Knowledge and Support

4. Imaging Consortium Team 3

5. Mission of the Imaging Consortium Expand imaging in clinical research Build infrastructure (software, image analysis and visualization tools, cross-site acquisition tools) Provide expert consultation in the use of imaging as part of clinical translational research Educate and advise about available imaging and image processing capabilities in the Harvard environment. Provide education at the local and national level (participation in RSNA education program) 4

6. Image Consortium Consultation Service 5

7. Technologies and Expertise Cancer imaging, MRI, PET, CT, fMRI, US, pediatric imaging, neuroimaging. Focused on assisting with planning and design of research proposals and/or methods for image analysis. Consultation is available for the preparation of a grant or IRB submission. We do not (yet) provide ongoing support for the implementation of new studies or the analysis of data from existing studies. 6

8. Examples of Imaging Consultation • Standardization of physiologic monitoring system for MRI. • Deployed at 6 institutions (MGH, BWH.BIDMC, CHB, MIT, Harvard) • Creation of a biomedical engineerworking group 7

9. Examples of Imaging Consultation • Development of lingual nerve imaging (MGH-BIDMC) • MGH maxillofacial surgeon contacted us regarding pre-op imaging of lingual nerve • Bob Lenkinski (BIDMC) had expertise in MRI nerve imaging • Healthy volunteer was scanned at BIDMC • Head and neck radiologist (BIDMC) will help with reading of images 8

10. Examples of Imaging Consultation Optical Imaging of Cerebral Oxygenation in Infants (MGH) • Study of brain-development in premature infants (new collaboration: CHB-BWH-MGH) CHB: new Fetal-Neonatal Neuroimaging and Developmental Science Center Slicer (BWH): quantitative tractography (Gilmore, 2007 AJNR) 9

11. Medical Imaging Informatics Examples: Clinical: Ruling out appendicitis based on CT scans. Are there metrics that can be found by analyzing clinical data? Quantitative output from Freesurfer for Alzheimer disease Research: Helping TIMC get easier access to PACS system for clinical trials 10

12. Medical Imaging Informatics IT Catalyst infrastructure: i2b2: scalable computational framework to help translation of genomic findings. BIRN: XNAT imaging informatics platform: large collections of images and study-specific metadata to be managed by image-driven clinical translational research groups. NA-MIC:robust, open source solutions for medical image analysis, visualization and management software tools by the creation of a “desktop” version of XNAT. Key image analysis software tools: Slicer, Freesurfer. 11

13. Medical Imaging Informatics XNAT Enterprise Dr Y Desktop Alzheimer Dr Z Desktop Chronic pain management Dr X Desktop Pediatric rare disease Dr W Desktop Quantitative cancer biomarkers PACS PACS Annotating Genomic Data #2 Project Management File Repository De - Identification Of data Ontology Management Identity Management Natural Language Processing Data Repository (CRC) Workflow Framework Annotating Genomic Data #1 Correlation Analysis 12 i2b2 HIVE

14. Educational Program Mission: Provide lectures, tutorials, and educational materials promoting the use of imaging to junior investigators and associated research staff Tailored lectures: Host on-site and based on discipline (oncology, neuro, cardiology, pediatrics, etc) Generic imaging modules: Basic principles of imaging, quantitative methods, clinical trial design with imaging endpoints, imaging risks and considerations for informed consent forms Dissemination: through national networks (CTSA, RSNA, IRAT, SNM) 13

15. Pilot funds • Eligibility:All Harvard faculty are eligible to apply, regardless of degree or institutional affiliation. • First round: 62 projects funded (out of 602) • Funds:Pilot Grants will be awarded in the amount of $50,000, with an award period of one year. (80 grants expected) • Deadlines:Letter of intent: May 13, 2009 Full application: June 12, 2009 • Contact:Harvard Catalyst Research Navigators617 432-7800

16. http://catalyst.harvard.edu Image_Consult@catalyst.harvard.edu www.na-mic.org/Wiki/index.php/Collaboration:Harvard_CTSC