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Overview of the Harvard Catalyst Imaging program

Overview of the Harvard Catalyst Imaging program. Randy Gollub,MD,PhD; Ron Kikinis, MD; Bruce Rosen, MD, PhD;Clare Tempany, MD; Valerie Humblet, PhD. April 14, 2009. Harvard Catalyst: The History and the Basics. GCRC program (20+ yr NCRR/NIH funded clinical trials program) discontinued

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Overview of the Harvard Catalyst Imaging program

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  1. Overview of the Harvard Catalyst Imaging program Randy Gollub,MD,PhD; Ron Kikinis, MD; Bruce Rosen, MD, PhD;Clare Tempany, MD; Valerie Humblet, PhD April 14, 2009 http://catalyst.harvard.edu

  2. Harvard Catalyst: The History and the Basics GCRC program (20+ yr NCRR/NIH funded clinical trials program) discontinued BWH/MGH imaging cores CTSA 2007(Roadmap initiative) HU- Response-Harvard Catalyst (PI Lee Nadler/Co-Director: Steve Freedman) GCRC at BWH incorporated in Center for Clinical Investigation We are a pan-Harvard enterprise dedicated to improving human health by: Creating Connections Enabling research At the Cutting Edge of discovery Nurturing clinical and translational researchers 1

  3. National Effort in C/T Research38 AHC/23 states Mayo Clinic Northwestern UC Davis Cornell J.Hopkins Duke Emory U. Wash. U. • Imaging programs-(Dan Sullivan/RSNA) Source: http://www.ctsaweb.org/ • Member of the NCRR Clinical and Translational Science Award (CTSA) Consortium-14 new in 08 2

  4. Institutions participating in Harvard CTSC Yearly budget: $38 million (23 NIH + 15 matching) Academic Healthcare Centers • Beth Israel-Deaconess Medical Center • Brigham and Women’s Hospital • Massachusetts General Hospital • Children’s Hospital Boston Specialty Hospitals and Institutes • Dana-Farber Cancer Institute • Forsyth Dental Institute • Joslin Diabetes Center • Massachusetts Eye and Ear Infirmary • McLean Hospital • Schepens Eye Research Institute Massachusetts Institutes of Technology Harvard University • Faculty of Arts and Sciences • Harvard Business School • Harvard School of Dental Medicine • Harvard Divinity School • Graduate School of Design • Graduate School of Education • Kennedy School of Government • Harvard Law School • Harvard Medical School • Harvard School of Public Health • Harvard School of Engineering Community Healthcare Institutions • Cambridge Health Alliance • HMS Department of Ambulatory Care and Prevention at Harvard Pilgrim Healthcare 3 Red –Imaging Consortium

  5. Harvard Catalyst • Programs (Selected list) • Development of Novel C/T Methodologies • Biomedical Informatics • Research Education, Career Development • Pilot studies • Community Engagement • Design and Biostatistics • Diversity and Health Disparities Research • Ethics • Linkages across the institutions • Regulatory Knowledge and Support

  6. Harvard Catalyst • Programs • Translational Technologies and Resources • Imaging and Genetics • increases investigator awareness and utilization of established translational technologies, educates the research community in the underlying principles and application of relevant translational technologies and fosters collaborations to improve these technologies.

  7. Imaging Consortium Team 6

  8. Mission of the Imaging Consortium Expand imaging in clinical research Build infrastructure (software, image analysis and visualization tools, cross-site acquisition tools) Provide expert consultation in the use of imaging as part of clinical translational research Educate and advise about available imaging and image processing capabilities in the Harvard environment. Provide education at the local and national level (participation in RSNA education program) 7

  9. Harvard Catalyst website http://catalyst.harvard.edu/home.html 8

  10. Harvard Catalyst website

  11. Image Consortium Consultation Service 10

  12. Image Consortium Consultation Service 11

  13. Technologies and Expertise Cancer imaging, MRI, PET, CT, fMRI, US, pediatric imaging, neuroimaging. Focused on assisting with planning and design of research proposals and/or methods for image analysis. Consultation is available for the preparation of a grant or IRB submission. We do not (yet) provide ongoing support for the implementation of new studies or the analysis of data from existing studies. 12

  14. Examples of Imaging Consultation • Standardization of physiologic monitoring system for MRI. • Development of lingual nerve imaging (MGH-BIDMC) • Multi-site structural and functional neuroimaging (BIDMC-MGH) 13

  15. Examples of Imaging Consultation Optical Imaging of Cerebral Oxygenation in Infants (MGH) • Study of brain-development in premature infants (CHB-BWH-MGH) CHB: new Fetal-Neonatal Neuroimaging and Developmental Science Center Slicer (BWH): quantitative tractography (Gilmore, 2007 AJNR) 14

  16. Medical Imaging Informatics Examples: Clinical: Ruling out appendicitis based on CT scans. Are there metrics that can be found by analyzing clinical data? Quantitative output from Freesurfer for Alzheimer disease Research: Helping TIMC get easier access to PACS system for clinical trials 15

  17. Medical Imaging Informatics IT Catalyst infrastructure: i2b2: scalable computational framework to help translation of genomic findings. BIRN: XNAT imaging informatics platform: large collections of images and study-specific metadata to be managed by image-driven clinical translational research groups. NA-MIC:robust, open source solutions for medical image analysis, visualization and management software tools by the creation of a “desktop” version of XNAT. Key image analysis software tools: Slicer, Freesurfer. 16

  18. Medical Imaging Informatics XNAT Enterprise Dr Y Desktop Alzheimer Dr Z Desktop Chronic pain management Dr X Desktop Pediatric rare disease Dr W Desktop Quantitative cancer biomarkers PACS PACS Annotating Genomic Data #2 Project Management File Repository De - Identification Of data Ontology Management Identity Management Natural Language Processing Data Repository (CRC) Workflow Framework Annotating Genomic Data #1 Correlation Analysis 17 i2b2 HIVE

  19. Educational Opportunities proposal Nanocourse: Imaging 101 to increase knowledge about imaging More advanced classes for radiologists: Tumor metrics Radiation safety issues for IRB submission Hands-on classes on data analysis Imaging perfusion Example: www.na-mic.org/Wiki/images/8/8b/Slicer3Training_ChangeTracker.ppt 18

  20. Pilot funds • Eligibility:All Harvard faculty are eligible to apply, regardless of degree or institutional affiliation. • First round: 62 projects funded (out of 602) • Funds:Pilot Grants will be awarded in the amount of $50,000, with an award period of one year. (80 grants expected) • Deadlines:Letter of intent: May 13, 2009 Full application: June 12, 2009 • Contact:Harvard Catalyst Research Navigators617 432-7800

  21. http://catalyst.harvard.edu Image_Consult@catalyst.harvard.edu www.na-mic.org/Wiki/index.php/Collaboration:Harvard_CTSC

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