Development of Harvard Catalyst Imaging Consultation Service

1. Development of Harvard Catalyst Imaging Consultation Service C.Tempany, MD; R.Kikinis, MD; R.Gollub,MD,PhD; V. Humblet, PhD February 27,2009 http://catalyst.harvard.edu

2. Agenda • Harvard Catalyst • Imaging Consortium • Technology and Expertise • IT Structure • Why be a consultant ? • Educational Opportunities • Contact

3. Harvard Catalyst: The History and the Basics GCRC program (20+ yr NCRR/NIH funded clinical trials program) discontinued BWH/MGH imaging cores (CT/AVD/GS) CTSA 2007(Roadmap initiative-EAZ) HU- Response-Harvard Catalyst (PI Lee Nadler/Co-Director: Steve Freedman) We are a pan-Harvard enterprise dedicated to improving human health by: Creating Connections Enabling research At the Cutting Edge of discovery Nurturing clinical and translational researchers 2

4. National Effort in C/T Research38 AHC/23 states Mayo Clinic Northwestern UC Davis Cornell J.Hopkins Duke Emory U. Wash. U. • Imaging programs-(Dan Sullivan/RSNA) Source: http://www.ctsaweb.org/ • Member of the NCRR Clinical and Translational Science Award (CTSA) Consortium-14 new in 08 3

5. Institutions participating in Harvard CTSC Year 01 total budget: $22,148,106 Academic Healthcare Centers • Beth Israel-Deaconess Medical Center • Brigham and Women’s Hospital • Massachusetts General Hospital • Children’s Hospital Boston Specialty Hospitals and Institutes • Dana-Farber Cancer Institute • Forsyth Dental Institute • Joslin Diabetes Center • Massachusetts Eye and Ear Infirmary • McLean Hospital • Schepens Eye Research Institute Massachusetts Institutes of Technology Harvard University • Faculty of Arts and Sciences • Harvard Business School • Harvard School of Dental Medicine • Harvard Divinity School • Graduate School of Design • Graduate School of Education • Kennedy School of Government • Harvard Law School • Harvard Medical School • Harvard School of Public Health • Harvard School of Engineering Community Healthcare Institutions • Cambridge Health Alliance • HMS Department of Ambulatory Care and Prevention at Harvard Pilgrim Healthcare Red –Imaging Consortium 4

6. Harvard catalyst • Programs (Selected list) • Biomedical Informatics-Kohane • Community engagement • Design and Biostats • Dev of Novel CT methodologies-Vikas • Diversity/Health Disparities research • Ethics • Linkages-HL, HBS, Kennedy School etc • Pilot studies • Regulatory-BB • Research Education

7. Harvard catalyst • Programs • Translational Technologies and Resources-GW • Imaging • increases investigator awareness and utilization of established translational technologies, educates the research community in the underlying principles and application of relevant translational technologies and fosters collaborations to improve these technologies.

8. Pilot funds • Eligibility:Any individual with a Harvard faculty appointment regardless of degree. • Funds:Pilot grants ranging from $40,000 to $100,000 for one year. Majority of the awards will be in the $50,000 to $75,000 range. Application for second year of funding will be considered if benchmarks are achieved. Occasionally grants up to $200,000 will be awarded. • Deadlines: RFA Posted for Round One - September 4, 2008 Preliminary Proposal (two page) Due - October 15, 2008 Semi-Finalists Selected - November 7, 2008 Secondary Application (5 pages) Due - December 7, 2008 Round One Pilots Grants Funded - January 15, 2009 • Contact: Harvard Catalyst Research NavigatorsE-mail 617 432-7800

9. Imaging Consortium Team 8

10. Mission of the Imaging Consortium Provide expert consultation and guidance to CTSC participants in the use of imaging as part of clinical translational research Educate and advise Harvard and the Affiliated Academic Health Centers about available imaging and image processing capabilities in the Harvard environment. 9

11. Harvard Catalyst website Access to resources and profiles http://catalyst.harvard.edu/home.html 10

12. Image Consortium Consultation Service Access to the consultation service: http://catalyst.harvard.edu/home.html 11

13. Technologies and Expertise Cancer imaging, MRI, PET, CT, fMRI, pediatric imaging, neuroimaging. Focused on assisting with planning and design of research proposals and/or methods for image analysis. Consultation is available for the preparation of a grant or IRB submission. We do not provide ongoing support for the implementation of new studies or the analysis of data from existing studies. 12

14. XNAT-PACS-i2b2 Integration IT Catalyst infrastructure: i2b2: scalable computational framework to help translation of genomic findings. BIRN: XNAT imaging informatics platform: large collections of images and study-specific metadata to be managed by image-driven clinical translational research groups. NA-MIC:robust, open source solutions for medical image analysis, visualization and management software tools by the creation of a “desktop” version of XNAT. Key image analysis software tools: slicer. Freesurfer. 13

15. XNAT-PACS-i2b2 Integration XNAT Enterprise Dr Y Desktop Alzheimer Dr Z Desktop Chronic pain management Dr X Desktop Pediatric rare disease Dr W Desktop Quantitative cancer biomarkers PACS PACS Annotating Genomic Data #2 Project Management File Repository De - Identification Of data Ontology Management Identity Management Natural Language Processing Slicer: Data visualization analysis Data Repository (CRC) Workflow Framework Annotating Genomic Data #1 Correlation Analysis 14 i2b2 HIVE

16. Becoming an Imaging Consultant Potential benefits of being an active collaborator: Good framework for research Research opportunities through collaborations Meeting experts out of radiology Networking with imaging cores outside of Boston Example: standardization of physiologic monitoring system for fMRI 15

17. Educational Opportunities proposal Nanocourse: Imaging 101 More advanced classes: Tumor metrics Radiation safety issues for IRB submission Hands-on classes on data analysis Imaging perfusion Example: www.na-mic.org/Wiki/images/8/8b/Slicer3Training_ChangeTracker.ppt 16

18. http://catalyst.harvard.edu Image_Consult@catalyst.harvard.edu www.na-mic.org/Wiki/index.php/Collaboration:Harvard_CTSC