Overview of the Harvard Catalyst Imaging program

1. Overview of the Harvard Catalyst Imaging program Ron Kikinis, MD;Clare Tempany, MD; Valerie Humblet, PhD July 20, 2009 http://catalyst.harvard.edu

2. Harvard Catalyst: The History and the Basics GCRC program (20+ yr NCRR/NIH funded clinical trials program) discontinued BWH/MGH imaging cores CTSA 2007(Roadmap initiative) HU- Response-Harvard Catalyst (PI Lee Nadler/Co-Director: Steve Freedman) GCRC at BWH incorporated in Center for Clinical Investigation We are a pan-Harvard enterprise dedicated to improving human health by: Creating Connections Enabling research At the Cutting Edge of discovery Nurturing clinical and translational researchers 1

3. National Effort in C/T Research39 AHC/23 states Mayo Clinic Northwestern UC Davis Cornell J.Hopkins Duke Emory U. Wash. U. • 30 Imaging programs-(Dan Sullivan/RSNA) Source: http://www.ctsaweb.org/ • Member of the NCRR Clinical and Translational Science Award (CTSA) Consortium 2

4. Institutions participating in Harvard CTSC Yearly budget: $38 million (23 NIH + 15 matching) Academic Healthcare Centers • Beth Israel-Deaconess Medical Center • Brigham and Women’s Hospital • Massachusetts General Hospital • Children’s Hospital Boston Specialty Hospitals and Institutes • Dana-Farber Cancer Institute • Forsyth Dental Institute • Joslin Diabetes Center • Massachusetts Eye and Ear Infirmary • McLean Hospital • Schepens Eye Research Institute Massachusetts Institutes of Technology Harvard University • Faculty of Arts and Sciences • Harvard Business School • Harvard School of Dental Medicine • Harvard Divinity School • Graduate School of Design • Graduate School of Education • Kennedy School of Government • Harvard Law School • Harvard Medical School • Harvard School of Public Health • Harvard School of Engineering Community Healthcare Institutions • Cambridge Health Alliance • HMS Department of Ambulatory Care and Prevention at Harvard Pilgrim Healthcare 3 Red –Imaging Consortium

5. Harvard Catalyst • Programs (Selected list) • Development of Novel C/T Methodologies • Biomedical Informatics • Research Education, Career Development • Pilot studies • Community Engagement • Design and Biostatistics • Diversity and Health Disparities Research • Ethics • Linkages across the institutions • Regulatory Knowledge and Support

6. Harvard Catalyst • Programs • Translational Technologies and Resources • Imaging and Genetics • increases investigator awareness and utilization of established translational technologies, educates the research community in the underlying principles and application of relevant translational technologies and fosters collaborations to improve these technologies.

7. Imaging Consortium Team 6

8. Mission of the Imaging Consortium Expand imaging in clinical research Build & deploy infrastructure (expertise in single and cross site image acquisition, image analysis, visualization & data management software tools) Provide expert consultation in the use of imaging as part of clinical translational research Educate and advise about available imaging and image processing capabilities in the Harvard environment. Provide leadership & education at the local and national level 7

9. Harvard Catalyst website http://catalyst.harvard.edu/home.html 8

10. Image Consortium Consultation Service 9

11. Image Consortium Consultation Service 10

12. Technologies and Expertise Cancer imaging, MRI, PET, CT, fMRI, US, pediatric imaging, neuroimaging. Focused on assisting with planning and design of research proposals and/or methods for image analysis. Consultation is available for the preparation of a grant or IRB submission. We do not (yet) provide ongoing support for the implementation of new studies or the analysis of data from existing studies. 11

13. Examples of Imaging Consultation • Standardization of physiologic monitoring system for MRI. • Deployed at 6 institutions (MGH, BWH, BIDMC, CHB, MIT, Harvard) • Creation of a biomedical engineerworking group 12

14. Examples of Imaging Consultation • Development of lingual nerve imaging (MGH-BIDMC) • MGH maxillofacial surgeon contacted us regarding pre-op imaging of lingual nerve • Bob Lenkinski (BIDMC) had expertise in MRI nerve imaging • Healthy volunteer was scanned at BIDMC • Head and neck radiologist (BIDMC) will help with reading of images 13

15. Examples of Imaging Consultation Optical Imaging of Cerebral Oxygenation in Infants (MGH) • Study of brain-development in premature infants (CHB-BWH-MGH) CHB: new Fetal-Neonatal Neuroimaging and Developmental Science Center Slicer (BWH): quantitative tractography (Gilmore, 2007 AJNR) 14

16. CTSCImagingInformaticsMission Provide imaging informatics services and support to Harvard Catalyst affiliated – Individual investigators – Organizations (departments, centers, hospitals) Enable medical imaging data sharing across individual investigators and organizations with dedicated hardware and software Integrate Imaging Data Management capabilities into i2b2 15

17. CTSCImagingInformatics IT Catalyst infrastructure: i2b2: scalable computational framework to help translation of genomic findings. BIRN: XNAT imaging informatics platform: large collections of images and study-specific metadata to be managed by image-driven clinical translational research groups. NA-MIC:robust, open source solutions for medical image analysis, visualization and management software tools by the creation of a “desktop” version of XNAT. Key image analysis software tools: Slicer, Freesurfer. 16

18. CTSCImagingInformatics XNAT Enterprise Dr Y Desktop Alzheimer Dr Z Desktop Chronic pain management Dr X Desktop Pediatric rare disease Dr W Desktop Quantitative cancer biomarkers PACS PACS Annotating Genomic Data #2 Project Management File Repository De - Identification Of data Ontology Management Identity Management Natural Language Processing Data Repository (CRC) Workflow Framework Annotating Genomic Data #1 Correlation Analysis 17 i2b2 HIVE

19. CTSCImagingInformatics Secondary Use of Clinical Imaging Data (Integration with i2b2) Automated MRI measures identify individuals with mild cognitive impairments and Alzheimer’s disease Desikan et al, Brain (published online on May 21, 2009) Standard T1 MRI scan AUC 0.95 (specificity 91%, sensitivity 90% to discriminate) MCI from age matched controls 18

20. Catalyst Educational Program • Creation of a new Harvard post-graduate education program in C/T science (Elliott Antman, BWH) • Introduction to Clinical Investigator TrainingFirst course: Nov 2-6, 2009 • Advanced Clinical Research Training To prepare investigators for writing and conducting a clinical trial • Masters K12 Programs Preparation for career in clinical research 19

21. Imaging Consortium Educational Program • Mission: Provide lectures, tutorials, and educational materials promoting the use of imaging to junior investigators and associated research staff • Tailored lectures: Host on-site and based on discipline (oncology, neuro, cardiology, pediatrics, etc) • Generic imaging modules: Basic principles of imaging, quantitative methods, clinical trial design with imaging endpoints, imaging risks and considerations for informed consent forms • Dissemination: through national networks (CTSA, RSNA, IRAT, SNM) 20

22. Pilot grants • To foster cross-institutional and cross-disciplinary collaboration, Harvard Catalyst offers seed funds in the form of Pilot Grants. • All Harvard faculty are eligible to apply, regardless of degree or institutional affiliation. • First round: 62 projects funded (out of 602) • This year (application closed): Pilot Grants will be awarded in the amount of $50,000, with an award period of one year. (80 grants expected) • Contact:Harvard Catalyst Research Navigators617 432-7800

23. http://catalyst.harvard.edu Image_Consult@catalyst.harvard.edu www.na-mic.org/Wiki/index.php/Collaboration:Harvard_CTSC