Development of Harvard Catalyst Imaging Consultation Service

1. Development of Harvard Catalyst Imaging Consultation Service Simon K. Warfield, Ph.D. Valerie Humblet, Ph.D. on behalf of the CTSC Imaging Committee http://catalyst.harvard.edu

2. Outline • Harvard Catalyst • Imaging Consortium • Technology effort: Inter-site data exchange • Why be a consultant ? • Contact

3. Harvard Catalyst: The Basics We are a cross-Harvard enterprise dedicated to improving human health by: Creating Connections Enabling research At the Cutting Edge of discovery Nurturing clinical and translational researchers 2

4. National Effort in C/T Research Source: http://www.ctsaweb.org/ • Member of the NCRR Clinical and Translational Science Award (CTSA) Consortium 3

5. Institutions participating in Harvard CTSC Hospitals and Institutes • Beth Israel-Deaconess Medical Center • Brigham and Women’s Hospital • Massachusetts General Hospital • Children’s Hospital Boston • Dana-Farber Cancer Institute • Forsyth Dental Institute • Joslin Diabetes Center • Massachusetts Eye and Ear Infirmary • McLean Hospital • Schepens Eye Research Institute Massachusetts Institute of Technology Harvard University • Faculty of Arts and Sciences • Harvard Business School • Harvard School of Dental Medicine • Harvard Divinity School • Graduate School of Design • Graduate School of Education • Kennedy School of Government • Harvard Law School • Harvard Medical School • Harvard School of Public Health • Harvard School of Engineering Community Healthcare Institutions • Cambridge Health Alliance • HMS Department of Ambulatory Care and Prevention at Harvard Pilgrim Healthcare 4

6. Mission of the Imaging Consortium Provide expert consultation and guidance to CTSC participants in the use of imaging as part of clinical translational research Educate and advise Harvard and the Affiliated Academic Health Centers about available imaging and image processing capabilities in the Harvard environment. 5

7. Imaging Consortium Team 6

8. Inter-site data exchange XNAT Enterprise Dr Y Desktop Alzheimer Dr Z Desktop Chronic pain management Dr X Desktop Pediatric rare disease Dr W Desktop Quantitative cancer biomarkers PACS PACS Annotating Genomic Data #2 Project Management File Repository De - Identification Of data Ontology Management Identity Management Natural Language Processing Data Repository (CRC) Workflow Framework Annotating Genomic Data #1 Correlation Analysis 7 i2b2 HIVE

9. Becoming an Imaging Consultant Potential benefits of volunteering to be a consultant: Networking leading to collaborations and funding (eg: pilot grants) Increase user base of service Mentoring new investigators 8

10. Radiology at Children’s Hospital • Expertise in Pediatric Imaging • Image analysis algorithms especially suited to pediatrics • Software implementation supported by NIH to create a platform for scientific discovery: • Computational Radiology Kit (CRKit) • Open source software

11. Radiology at Children’s Hospital • Computational Radiology Kit (CRKit) • Pediatric MRI image segmentation • Intra-subject multi-modality image fusion • Inter-subject alignment • Neuroimage atlasing • Diffusion tensor image group analysis for RCT • Tractography • Visualization • Validation for quantitative image analysis

12. http://catalyst.harvard.edu Image_Consult@catalyst.harvard.edu