1 / 4

NON-CATECHOLAMINES

NON-CATECHOLAMINES. Selective α 1 agonists: Phenylephrine & methoxamine Powerful direct stimulants of α 1 -receptors  v.c . of b.v .   PVR. They  B.P. with reflex bradycardia (this effect is more prolonged than that of NE). Metabolized by MAO, but not by COMT.

jacoba
Download Presentation

NON-CATECHOLAMINES

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. NON-CATECHOLAMINES

  2. Selective α1 agonists: • Phenylephrine & methoxamine • Powerful direct stimulants of α1-receptors  v.c. of b.v.  PVR. • They  B.P. with reflex bradycardia (this effect is more prolonged than that of NE). • Metabolized by MAO, but not by COMT. • Methoxamine has a longer duration of action.

  3. Uses: • Locally: nasal and ocular decongestant to treat rhinitis and conjunctivitis. • Maintenance of B.P. during surgery. • Treatment of hypotension caused by excessive doses of vasodilators or drug induced shock.

  4. Midodrine: • A prodrug that is enzymatically hydrolyzed to desglymidodrine (α1 agonist) • Uses: treatment of postural hypotension. • Oxymetazoline (specific α2a agonist) & Xylometazoline: • Uses: topical decongestants because of their ability to promote v.c. of the nasal mucosa.

More Related