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A N E M I A A P L A S T I K

A N E M I A A P L A S T I K. IRZA WAHID FAKULTAS KEDOKTERAN UNIVERSITAS ANDALAS PADANG 2012. Nama : Dr H Irza Wahid SpPD KHOM Tempat / Tanggal Lahir : Padang / 23 November 1967 Alamat : Jalan Kolam Indah Raya No A6 Cendana Mata Air Pdg

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A N E M I A A P L A S T I K

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  1. A N E M I A A P L A S T I K IRZA WAHID FAKULTAS KEDOKTERAN UNIVERSITAS ANDALAS PADANG 2012

  2. Nama : Dr H Irza Wahid SpPD KHOM Tempat / Tanggal Lahir : Padang / 23 November 1967 Alamat : Jalan Kolam Indah Raya No A6 Cendana Mata Air Pdg Telp. : 075161952 – 08126605439 Pekerjaan : Kepala Subagian Hematologi – Onkologi Medik Bagian Ilmu Penyakit dalam FK Unand / RS Dr M Djamil RIWAYAT PENDIDIKAN

  3. ANEMIA Parameter : Kadar hemoglobin  MetodeSahliPriadewasa : Wanitadewasa : Hamil : Hb < 13 : < 12 : < 11 gr %  Gejaladantanda Hbhipoksiakompensasikardiovaskular * Pucat * angina pektoris * kardiomegali Mukosa * claudicatiointermiten * palpitasi Kulit * tinitus * dispneu * berkunang * bisingsistolik * cepatlelah * gagaljantung Gradasianemia ringan : sedang : berat : > 8 : 6 – 8 : < 6 gr % Morfologi mikro / normo / makrositer -- hipo/normo/hiperkrom Patofisiologi defisiensi – aplastik – hemolitik – perdarahan Etiologi  Cacing, low intake, kelainanimun, trauma

  4. PATHOPHYSIOLOGY OF ANEMIA • 1. Deficient RBC production • 2.RBC Loss without RBC destruction • 3. Increased RBC destruction over production

  5. Deficient RBC Production • Neoplasia • Leukemia • Metastasis to bone marrow • Osteogenic sarcoma • Myelofibrosis • Pernicious anemia • Iron Deficiency anemia • Aplastic anemia • Chloramphenicol administration • Renal disease (lack of erythropoietin production) • Increased RBC destruction over erythropoiesis

  6. Pathophysiology of aplastic anemia • The primary defect is a reduction in or depletion of hematopoietic precursor stem cells with decreased production of all cell lines. This is what leads to the peripheral pancytopenia. • This may be due to quantitative or qualitative damage to the pluripotential stem cell. • In rare instances it is the result of abnormal hormonal stimulation of stem cell proliferation • or the result of a defective bone marrow microenvironment • or from cellular or humoralimmunosuppression of hematopoiesis.

  7. What is Aplastic Anemia? Aplastic Anemia is a bone marrow failure disease. Red Blood Cell Platelets White Blood Cell Help to save a Life

  8. 2008

  9. ETIOLOGI • Idiopatik • Sekunder : bilakausanyadiketahui radiasi, kemoterapi, antibiotik ( kloramfenikol ), virus (Hepatitis, EBV, HIV, mikobakterium ) • Herediter : SindromaFanconi

  10. MANIFESTASI KLINIK • Anemia • Infeksi • Perdarahan • Tak ada organomegali

  11. Functions of Blood Cells • Red Blood Cells Carry oxygen to all body organs • White Blood Cells Fight infection and keep you healthy • Platelets Help control bleeding Help to save a Life

  12. LABORATORIUM • Anemia, leukopeni, trombositopeni • Retikulosit menurun • Normositer, normokrom • SST  Hiposeluler

  13. GRADASI

  14. PENATALAKSANAAN • Stop / hindarikontakpenyebab • Umum • Imunosupresif • Stimulasihemopoitik • Transplantasisumsumtulang

  15. Treatment Options Bone Marrow Transplant Growth fcHormones Immune Suppressive Therapy Supportive Care Help to save a Life

  16. SUPPORTIVE CARE- BLOOD TRANSFUSION PRC  TC- ANTIBIOTICS

  17. THANK YOU

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