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PENGANTAR FARMAKOLOGI

PENGANTAR FARMAKOLOGI. FARMAKO KINETIK. Nasib obat di dalam tubuh Absorpsi Distribusi Metabolisme Ekskresi. FARMAKO DINAMIK. Efek obat terhadap fisiologi dan biokimia berbagai organ tubuh, serta mekanisme kerja obat tsb. Cara Pemberian Obat. Per oral: telan Sub lingual: di bawah lidah

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PENGANTAR FARMAKOLOGI

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  1. PENGANTAR FARMAKOLOGI

  2. FARMAKO KINETIK Nasib obat di dalam tubuh • Absorpsi • Distribusi • Metabolisme • Ekskresi

  3. FARMAKO DINAMIK Efek obat terhadap fisiologi dan biokimia berbagai organ tubuh, serta mekanisme kerja obat tsb.

  4. Cara Pemberian Obat • Per oral: telan • Sub lingual: di bawah lidah • Sub bukal: bawah mukosa pipi • Par entral: melalui suntikan a. Intravena atau intra arteri b. Intra muskular c. Intra kutan d. Subkutan

  5. Cara Pemberian Obat (2) 5. Inhalasi: hirup 6. Per rectal: melalui anus 7. Per vaginal: melalui vagina 8. topikal: berupa krim atau obat tetes 9. Intra tekal : melalui otak

  6. EFEK OBAT • Efek KLINIK • Efek SAMPING • Efek TOKSIK

  7. Proses Obat dalam Tubuh ADSORBSI EKSKRESI EFEK DISTRIBUSI DISTRIBUSI MAKROMULEKULAR TARGET RESEPTOR ENZIM- ENZIM PROTEIN

  8. FARMAKO EKSPERIMENTAL • FASE 1 Menguji keamanan obat (dosis) Mengetahui farmako kinetik dan dinamiknya 2. FASE 2 Membuktikan efeknya (pada pnderita) Gunakan plasebo ( kapsul dengan tepung obat, tanpa ekstrak obat tertentu)

  9. FARMAKO EKSPERIMENTAL (2) • FASE 3 Memastikan efeknya Ada pembanding obat Multi center 2. FASE 4 Post marketing

  10. Terima Kasih.. Terima Kasih..

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