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Understanding Aneuploidy Causes and Consequences in Meiosis

Aneuploidy results from chromosome segregation issues during meiosis. Learn about non-disjunction in trisomic progenies inheriting different or identical alleles from parents. Aneuploids often produce aneuploid offspring due to unpaired chromosomes.

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Understanding Aneuploidy Causes and Consequences in Meiosis

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  1. FIGURA 7.20 L’aneuploidia è causata da problemi nella segregazione dei cromosomi alla meiosi. (A) Se una progenie trisomica eredita da un genitore due diversi alleli (A e a) di un gene strettamente associato al centromero, la non-disgiunzione sarà avvenuta alla meiosi I (a sinistra). Se i due alleli ereditati da un genitore sono uguali (A e A; o a e a), la non-disgiunzione sarà avvenuta alla meiosi II (a destra). (B) Poiché gli aneuploidi trasportano cromosomi che non hanno un omologo a cui appaiarsi, gli individui aneuploidi producono di frequente una progenie aneuploide. (Da: Hartwell et al., 2004.)

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