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Cardiovascular Consortium Effective Health Care Program

Cardiovascular Consortium Effective Health Care Program. Art Sedrakyan, MD, PhD Center for Outcomes & Evidence, AHRQ. Heart Disease is No. 1 Killer of Women. And Men Too…. Age Adjusted Death Rates in USA. National NIH 2007, chartbook on morbidity and mortality. Heart Disease Deaths.

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Cardiovascular Consortium Effective Health Care Program

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  1. Cardiovascular ConsortiumEffective Health Care Program Art Sedrakyan, MD, PhD Center for Outcomes & Evidence, AHRQ

  2. Heart Disease is No. 1 Killer of Women • And Men Too…

  3. Age Adjusted Death Rates in USA National NIH 2007, chartbook on morbidity and mortality

  4. Heart Disease Deaths

  5. Effective Health Care Program Congress authorized AHRQ (section 1013 of MMA) to conduct research to improve the quality, effectiveness, and efficiency of Medicare and Medicaid programs. • Evidence synthesis (EPC program) • Transparent process of systematically reviewing and synthesizing evidence on treatment effectiveness • Identifying relevant knowledge gaps • Evidence generation (DECIDE and CERTS) • Development of new scientific knowledge to address knowledge gaps • Evidence translation (Eisenberg Center) • Communication of scientific information in plain language to policymakers, patients, and providers 6

  6. Effective Healthcare Program

  7. Lifecycle of CV initiative CV topic solicitation (public input) CV topic generation ( work with stakeholders) CV topic Nominated ( work with stakeholders) Enough information evaluate if all EHC criteria are met Not enough information work with stakeholder Need evidence review (use EPC) General Comparative Technical brief Need to generate new evidence (use DECIDE, CERT, other) Admin/Claims based study Registry (linked) based study New data collection EHC Criteria are not met

  8. Cardiovascular consortium: Comparative Effectiveness Reviews (CER) Inform decision makers and identify the gaps in knowledge Completed • Comparative Effectiveness of PCI and CABG for CAD • CER of Management Strategies for Renal Artery Stenosis • CER of ACEIs and ARBs for Hypertension In progress • CER of Combinations of Lipid-Modifying Agents • CER of Medical Therapies with or without ACEs or ARBs for Stable CAD • Effectiveness and Off-label Use of Recombinant Factor VIIa • Effectiveness of Radiofrequency Catheter Ablation (RFA) for Atrial Fibrillation • Technical Brief: Percutaneous Heart Valves

  9. Cardiovascular consortium: Generating new evidence • New direction with Main emphasis on using national registries and their linkages in comparative effectiveness research • The role of National Clinical Registries in the Cycle of Evidence • National registry based study to evaluate effectiveness of Drug Eluting Stents and optimal length of anticoagulation therapy • National registry based study of effectiveness of cardiac valve implants • Other local registry or claims based studies List of previous contributing studies at • http://effectivehealthcare.ahrq.gov/

  10. Our plan for today • CABG vs PCI: Evidence in evolution: Professor Mark Hlatky Stanford University • Clinical Registries in the Cycle of Evidence Professor Eric Peterson Duke University • Questions to presenters and discussion

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