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Lerner Research Institute 2007 Operations Report

Welcome. State of the GMI. Lerner Research Institute 2007 Operations Report. This program recognizes individuals who have taken special initiative to help others and enrich the workplace. 2009 LRI STAR Award Winners. Peter Balint Petra Platzer.

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Lerner Research Institute 2007 Operations Report

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  1. Welcome State of the GMI State of the GMI 1 Lerner Research Institute 2007 Operations Report

  2. This program recognizes individuals who have taken special initiative to help others and enrich the workplace 2009 LRI STAR Award Winners • Peter Balint • Petra Platzer There were 31 nominations submitted for 2008. Of the 10 winners chosen, GMI had 2 STARs – we’re very proud! State of the GMI 2

  3. GMI Employee of the Quarter Winners This award program offers an opportunity for GMI members to recognize peers for their accomplishments and contributions to GMI and being a pillar of Teamwork, Quality, Service or Innovation. • Christina Rigelsky3rd Quarter, 2008 • Nichole Prescott4th Quarter, 2008 • Todd Romigh 1st Quarter, 2009 State of the GMI 3

  4. State of the Cleveland Clinic Highlights State of the GMI 4 State of the GMI 4

  5. State of Cleveland Clinic - 2009 Status • Increased accuracy in medical care (EMR) and pharmacy data entry (CPOE) • Increased compliance and decreased delinquent medical records • Improved patient access with new facilities • Decreased complaints and increased patient satisfaction scores (above national average, but there is more work ahead) Quality:patient experience (ie. medical, physical & emotional) Innovation: Status • Research funding (including NIH) up 6% in 2008; publications up 5% • Building of a new, national Reference Lab Center by 105th St. • Partnerships with: Google and Microsoft for home monitoring CVS’s “Minute Clinics” for increased patient volume • Increased media coverage, brand awareness & non-Ohio presence (CC Abu Dhabi, Sheik Khalifa Medical Center, and Lou Ruvo Center for Brain Health) State of the GMI 5

  6. Contributors to Premature Mortality % Behavior Genetics Social Medical Access Environmental D.M. Cosgrove, MD, State of the Clinic, 2008 State of the GMI 6

  7. State of Cleveland Clinic - 2009 Teamwork:Key areas: HR, IT, Wellness, Patient Experience, Quality & Safety Status • Strategic Council’s 4 main initiatives in 2009: • Patient Experience • Operational Excellence • Growth • Integration of the Health System • Current strategic investments: • HR – employee engagement • IT – integration, upgrading, and streamlining multiple systems • Wellness – employee and patient benefits • Improving communication and messaging to all employees State of the GMI 7

  8. State of Cleveland Clinic - 2009 Service:patient and employee services given and received Status • Reduction of overall wait time for outpatient appointments by 5 days (Same day Appt Initiative) • Improved employee-focused benefits and wellness initiatives • Weight Watchers program (lost 75,000 pounds so far) • Smoking Cessation • Increased tuition reimbursement programs • Nursing Magnet Status for main campus & Fairview • 23andMe, a free service for physicians to participate in genomic screening • Increased Environmental Stewardship, by recycling medical waste, exploring alternate energy sources and reducing energy consumption State of the GMI 8

  9. State of Cleveland Clinic - 2009 Finances: Status • CC is strong overall and Florida is turning a profit for the first time • 90% of CC’s $5 billion revenue from patient revenue; patient portion is declining due to costs of expanding the facilities and payor mix change • Guiding Principles for handling the current economic crisis: • Maintain Patient Care • Preserve Jobs • Maintain compensation • Invest in the Future • Expense reduction actions taken thus far are working; Unlike other healthcare institutions, CC has not been forced to lay off any personnel For every $50,000 the Clinic can “save”, that translates to one job saved State of the GMI 9

  10. State of Cleveland Clinic - 2009 Key take-aways: • Initiatives overall are heading in the right direction • We should not get too comfortable with our successes • Take advantage of this opportunity and let it stimulate us to achieve our best Tom Brokaw:… “we cannot waste the opportunities that lie within this crisis; it isn’t what divides us that’s important; it’s what unites us – and we should continue to “Act as a Unit”….” State of the GMI 10

  11. State of the Genomic Medicine Institute 2008 Annual Report Charis Eng, MD, Ph.D., FACP, Chair & Director June 22, 2009 State of the GMI 11

  12. GMI Core Values • To be the expert base for the principles and practice of genomic medicine • To provide a work culture that enables us to bring genetics and genomics, through our research and clinics, into all subspecialties of the Cleveland Clinic’s healthcare system • To promote scholarly activity (research), academic clinical practice and education • To foster innovation ultimately directed at personalized genomic-based healthcare State of the GMI 12

  13. “Cores” GMB IGAC Genomics Research Labs CPGH The Research Triad GMI’s interdisciplinary design as a one-stop shop is aligned with the LRI’s Research Triad Mission and CC’s Tripartite academic mission State of the GMI 13

  14. New Personnel State of the GMI 14

  15. New Investigator Effie Sehayek, MDarrived June 2, 2008 • Research FocusGenetics of sterol metabolism and atherosclerotic cardiovascular diseases Genetics of fat absorption from the intestine • Academic AppointmentsAssistant Professor, Dept of Molecular Medicine, CCLCM • Funding / Awards Scored in top 15th percentile for recent R01 submission Effie Sehayek, MD Mike Greenberg postdoc Katie Lintner, Res Tech Laboratory Members: State of the GMI 15

  16. Marc Shapiro, M.D.Primary Appointment: Taussig Cancer Center • Specialty:Lung, Breast, GI cancer • CPGH role:Breast Cancer Clinical Geneticist New Clinicians Holly Pederson, M.D.Primary Appointment: Center for Specialized Women’s Health • Specialty:Breast Cancer • CPGH role:Cancer Genetics Fellowship State of the GMI 16

  17. Other Recruitment Highlights in 2008 • Stephanie Fritz, Patient Service Representative • Kristi Bennett, Eng lab postdoc • Deborah Zygmunt, Aldred lab Sr Technician • Jessi Mester, Genetic Counselor • Tom Oravec, Labmatrix Data Entry • Kathleen Babb, Research Admin Coordinator Stephanie Kristi Deb Jessi Tom Kathleen State of the GMI 17

  18. Other Recruitment Highlights in 2008 (cont’d) Gina • Gina Keeler, Clinical Manager • Joshua Cowgill, Serre lab Technician • Jim Hester, Serre lab Computing • Jessi Moline, Genetic Counselor • Michelle Maurer, Medical Secretary • Shirley Tao, Zhang lab postdoc Josh Jim Jessi Michelle Shirley State of the GMI 18

  19. Other Recruitment Highlights in 2008 (cont’d) Charissa Patty • Charissa Peterson, Eng lab Sr Technician • Patty Arscott, Genetic Counselor • Jason He, Eng lab postdoc • Hui-Hui Liu, Zhang lab postdoc • Shingo Ashida, Eng lab postdoc • Toni Bartling, Ting lab postdoc Jason Hui-Hui Shingo Toni State of the GMI 19

  20. Other Recruitment Highlights in 2009 (cont’d) Theresa Junying • Theresa Welgs, Genomics Core • Junying Lei, Eng lab Sr Technician • Min Zhu, Zhang lab postdoc • Monika Hanus, GC Assistant • Yiran Yang, Eng lab postdoc • Meredith Holt, Project Manager Min Monika Yi-Ran Meredith State of the GMI 20

  21. Other Recruitment Highlights in 2009 (cont’d) • Jeannie Choi, Ting lab Technician • Hadley Miller, Serre lab Technician Jeannie Hadley Since 2007, we have had 31 people join GMI! State of the GMI 21

  22. Translational Disease-Oriented Research & Clinical Programs State of the GMI 22

  23. Disease Emphasis of GMI Laboratories • Cancer • Cardiovascular • Pulmonary • Neuro-Psych • Type 2 Diabetes GMI’s Disease-Oriented Research Programs State of the GMI 23

  24. Cancer Heart, Vessels, Blood Bioethics & Health Policy *Ruth Farrell, M.D.*Eric Kodish, M.D.*Richard Sharp, Ph.D. *Wilson Tang, M.D. Genomic Medicine Cell Biology Lung *Jonathan Smith, Ph.D. Opthamology Brain & Spine *Elias Traboulsi, M.D. *Bruce Lamb, Ph.D. Pediatrics, Obstetrics & Specialties *Ruth Farrell, M.D. *Staff members with adjunct appointments in GMI. Adjunct Staff:Complement GMI’s Research and Clinical Programs State of the GMI 24

  25. Outreach to other Research and Clinical Programs • Multidisciplinary Programs • Asthma and Pulmonary Hypertension (Erzurum)GMI:Michaela Aldred, Christina Rigelsky • Barrett Esophagus/Esophageal Adenocarcinoma Consortium (Eng) • GMI:Charis Eng,Brandie Leach • Heritable Colorectal Cancer Multidisciplinary Research Group & High Risk Cancer (Church) • GMI: Charis Eng, David Serre, Angela Ting, Brandie Leach • Endocrine Neoplasia Genomics Research Group and Multidisciplinary Clinic (Eng)GMI: Charis Eng,Emily Edelman • Head and Neck Neoplasia Genetics & Genomics Research Group & High Risk Clinic • GMI: Michaela Aldred, Charis Eng, Emily Edelman • Von Hippel-Lindau Disease Multidisciplinary (Virtual) Clinic (Eng) • GMI: Charis Eng, Amy Shealy State of the GMI 25

  26. Gorlin Syndrome (Virtual) Clinic (Eng) • GMI: Charis Eng,Amy Shealy • Marfan Syndrome Multidisciplinary Clinic (Greenberg) • GMI:Rocio Moran, Christina Rigelsky • Tuberous Sclerosis Multidisciplinary Clinic (Gupta) • GMI: Rocio Moran, Charis Eng, Amy Shealy Outreach to other Research and Clinical Programs (cont’d) (new in 2008) • Gene Dosage and Disease Susceptibility Research Group (Nadeau) GMI: David Serre, Angela Ting • Diabetes Genomics Research Group (Serre) • GMI:David Serre • Neurofibromatosis Multidisciplinary Clinic (Rothner) • GMI: Vickie Zurcher, Rebecca Mitchell, Allison Schreiber • Hearing Management Clinic • GMI: Rocio Moran, Allison Schreiber • Vascular Anomalies Multidisciplinary Clinic • GMI: Rocio Moran, Amy Shealy State of the GMI 26

  27. CORS/DDIColon CancerGC: Brandie Leach • Hillcrest • Prenatal/PreconceptionGC: Diane Clements Satellite Genetics Clinic Expansion (new in 2009) • Vascular Surgery Clinic GC: Christina Rigelsky, Patrica Arscott • Vascular Medicine Clinic GC: Christina Rigelsky • Fairview Moll PavilionBreast Cancer GC: Kate Lynch, Shanna Gustafson • Beachwood • Cancer GC: Kate Lynch, Shanna Gustafson • Prenatal/PreconceptionGC: Diane Clements • Shaker • Developmental & Behavior Pediatrics APN: Rebecca Mitchell State of the GMI 27

  28. Publications & Education State of the GMI 28

  29. Publication Highlights State of the GMI 29

  30. Teaching:Cleveland Clinic Lerner College of Medicine Course Instructors • Primary Personnel • Michaela Aldred, Ph.D. • Charis Eng, M.D., Ph.D. • Pieter Faber, Ph.D. • Banu Gopalan, M.S. • Shanna Gustafson, M.S. • Rocio Moran, M.D. • Mohammed Orloff, Ph.D. • David Serre, Ph.D. • Amy Shealy, M.S. • Angela Ting, Ph.D. • Secondary Personnel • Marvin Natowicz, M.D., Ph.D. • Ruth Farrell, M.D. • Donna Hansel, Ph.D. • Eric Kodish, M.D. • Wilson Tang, M.D. • Elias Traboulsi, M.D. State of the GMI 30

  31. Teaching:Molecular Medicine Ph.D. ProgramCleveland Clinic Lerner College of Medicine of Case Western Reserve University Admissions Committee: GMI Representative: Michaela Aldred, Ph.D. Two of nine inaugural class students rotated in the Eng lab and one selected this lab for their thesis work. Ying Ni Inaugural Class State of the GMI 31

  32. Funding State of the GMI 32

  33. Total Research Funding (Internal & External) Federal Funding Trend $258 $245 $223 $202 $180 $166 $101 $97 $91 $90 $85 $84 $82 $76 $75 $73 $69 $68 2003 2004 2005 2006 2007 2008 LRI Research Funding Declines in NIH funding are being offset by gains in other federal non-NIH sources (i.e., DOD, NASA, DOE, etc.) State of the GMI 33

  34. Research Funding Highlights New Grants in 2008 • Charis Eng, M.D., Ph.D., NIH – PO1: “Genetic alterations that initiate follicular carcinogenesis” ($223 ADC, 5 yr); BCRF: “Genes that affect mitochondrial function as novel mediators of beast cancer susceptibility” ($129K ADC, 1yr); BCRF: “Differential biallelic expression of PTEN in patients with heterozygous germline PTEN mutations as a novel mechanism of modulation of breast cancer risk” ($79K ADC, 1yr); Hearst Foundation: “Inherited Breast Cancer Research Program ($150K ADC, 2 yr) • Aldred, Michaela, Ph.D., AHA: “Progenitor Cells in Pulmonary Hypertension” ($70K ADC, 4yr) • Zhang, Bin, Ph.D., NIH – March of Dimes: “Receptor-mediated ER-to-Golgi transport of Coagulation factors V and VIII: Deficiencies in the early secretory pathway as pathogenic mechanisms of congenital disorders” ($68K ADC, 2 yr); RO1: “Receptor-mediated ER-to-Golgi transport of Coagulation factors V and VIII” ($225K ADC, 5yr) New extramural funding in CY 2008 ~$1.1M ADC, or ~$5.9 million total funding State of the GMI 34

  35. Ambrose Monell Foundation: ($100K ADC, 3yr) • “Cancer Genomics Training Fellowship Program” • Arthur Blank Foundation • William W. Baker Family Foundation • Norma & Albert Geller • Roger & Sharon Vail Philanthropic Funding Dr. Eng received first endowed chair in Cancer Genomics Research: $1.5 million endowed chair funded by Sondra and Stephen Hardis to further Cancer Genomics Research State of the GMI 35

  36. Clinical Revenue • New Genetic Counseling service reimbursement model implemented; utilizes first genetic counseling-specific billing code • Decoupling Geneticist and Genetic Counselor billing schema has: • increased patient access • decreased patient appointment wait times • provided opportunities for satellite clinic service expansion • Two recent Cleveland Clinic initiatives: • Same Day Appointments • Provider-based billing • Net effect on clinical revenue is being analyzed GMI’s Center for Personalized Genetic Healthcare is a pioneer in transforming traditional clinical genetics services to a financially self-sustainable model with: • increased patient access • improved patient service State of the GMI 36

  37. Innovations & Commercialization • “eGMI” • Patient-entered family history tool • Collection of personal and family medical history information • Creation of pedigree • Automated risk assessment • Utilizes MyConsult/eCC and Progeny • 4 provisional patents filed • Charis Eng, M.D., Ph.D. (3) • Effie Sehayek, M.D. (1) State of the GMI 37

  38. Employee Engagement State of the GMI 38

  39. Gallup Employee Engagement SurveyMarch, 2008 5-point scale: 1= Highly disagree  5= Highly Agree * 38 GMI employees GMI Strengths GMI Opportunities GMI Commitment: “to make GMI the best workplace for GMIers” State of the GMI 39

  40. Engagement Initiatives • Communication Improvement: • Increased forums (Town Hall, open staff meetings, Newsletter, etc) • Employee Recognition: • GMI Employee of the Quarter award • Socializing Opportunities: • Summer Picnic and Table 45 Happy Hour • Job Expectation Clarification: • Review and redefining of all position’s key job responsibilities (KJR) • Creation of a Job Specification and Performance Roadmap (JSPR) • Organizational Chart Refinement: • Defining subunit structures and mission statements State of the GMI 40

  41. THE GENOMIC MEDICINE INSTITUTE Dr Eng Chair Key: Admin Support Staff Management Team Executive Team Business Advisory Board Director, Transl Devel Rerko Admin Asst Blount Manager, Integ Devel Platzer Admin Asst Wilcox Research Admin Coordinator Babb Computing Balint Research Genomics Core P Faber Center for Personalized Genetic Healthcare Dir: Eng Clinical Research Program Mgr: X GMI Enterprise Rerko Res Admin Cdtr Babb Cancer Genetics / General GeneticsClinic Med Dir: Eng / Moran Clinical Mgr: Keeler Project Mgr Holt eGMI Platzer Research Study/Prog Coordinators BiorepositoryMgr: X PI Admin Assts Blount/Wilcox MDs Eng Lab Aldred Lab Genetics Educ CdtrX IT Architect X Genetic Counselors Int Genomics & Analysis Mgr: Gopalan ANP Zhang Lab Ting Lab ReimbursementSpecialist DatabaseProj Mgr GC Bioinformatics/Biostatistics Labmatrix Serre Lab Sehayek Lab PSRs, GC Assts, Med Sec

  42. Engagement: Next Steps • Completion of all employee JSPRs • Continued implementation of constructive and regular performance feedback • Continued focus on improving communications • Continued supervisor/manager training to be “engaging managers” • Next round of subgroup meetings to identify next action item plans • 2009 Gallup survey: June 24 - July 17 • LRI goal: improve scores by 5% State of the GMI 42

  43. Community Benefit & Wellness State of the GMI 43

  44. Commit10 Challenge Program Rebecca Mitchell • Triathlon Club (runners, bikers, swimmers) Nichole Prescott Institute Diversity Program • GMI Members on Diversity Council 2008: Banu Gopalan, CoordinatorKylie Drake • Conversational English Program (CEP) • Todd Romigh (coach) • Several GMI participants Institute Wellness Program GMI TRIes State of the GMI 44

  45. Community Benefit • United Way campaign • Last year, CC raised $1.8 million for local community resource centers • In 2008, GMI had 45.2% participation • 2009 campaign about to begin; GMI team captain is ? • 2 GMI folks participated in “United Way Day of Caring” • LRI’s Harvest for Hunger- generated 215 pounds of food, $2,400 in donations • Bolton School Supplies- generated ~$16,000 of supplies • GMI Feature in Cleveland Clinic-Community Breakfast & the Community Service Booklet • Rebecca Mitchell, M.S.N, C.N.S., camp nurse at Knox County 4-H Camp resulted in Caitlin Pugh Scholarship Fund donations. State of the GMI 45

  46. 6th Intl Conference on the Biology of Childhood Renal CancersInvited Lecturer: Michaela Aldred, Ph.D. Educational & Outreach Highlights • Genetics Education Campaign Kickoff Dr. Eng, Dr. Traboulsi, Dr. Moran, Cheryl Scacheri and Champions “Genetics in Health and Disease” symposium • Cold Spring Harbor LaboratoryInvited Lecturer: David Serre, Ph.D • 8th Intl Anticancer Research Conference Invited Lecturer: Angela Ting, Ph.D. • 27th Annual Meeting of National Society of Genetic CounselorsSession Co-chair: Emily Edelman, M.S., CGCEducational Breakout Session: Amy Shealy, M.S., CGC State of the GMI 46

  47. 18th Annual Symposium of Society of Black Academic Surgeons Invited Lecture: Charis Eng, M.D., Ph.D. Educational Highlights(Continued) • Aspiring Physicians & Research Scientists ConferenceInvited Panelist: Mohammed Orloff, Ph.D. • Neurofibromatosis: A 21st Century Perspective Invited Participants: Vickie Zurcher, M.D., Rebecca Mitchell, MSN, C.N.S., Allison Schreiber, M.S., CGC • 6th Annual Pediatric Neurology Update Seminar Invited Presenter: Rocio Moran, M.D. • American Society of Human Genetics Invited Science Session: “Organismal and Cellular Phenotypes of Breast Cancer Susceptibility Genes”Chair: Charis Eng, M.D., Ph.D. • The CPGH Genetic Counseling Internship program trained 2 GC students State of the GMI 47

  48. WKYC: Family Health History Day Dr. Eng, Shanna Gustafson Special Events & Community Outreach • Cleveland Museum of Natural History • Exhibit: “RACE: Are we so different?” Dawn Caraballo • Genomics Town HallDawn Caraballo, Drs. Moran and Serre, Cheryl Scacheri • PBS: “In the Family” documentary Cheryl Scacheri (message board) • Minority Men’s Health Fair Dawn Caraballo • School, Library and Support Group talks in 2008 Over a dozen educational talks given by various GMI personnel in 2008 State of the GMI 48

  49. Awards & Honors • GMI was honored as the featured member of the month (August) by the Personalized Medicine Coalition • Charis Eng, MD, PhD, Chair GMI, named Chair of the Clinical Science Committee of the Personalized Medicine Coalition. • Charis Eng, MD, PhD was elected to the 2008-2009 Best Doctors in America database for her work in Clinical Cancer Genetics and Cancer Genomic Medicine. • Charis Eng, MD, PhD was a Visiting Professor in the Human Manpower Development Planning Programme of Singapore’s National Cancer Center • Charis Eng, MD, PhD was awarded the LRI Excellence Award for Outstanding Science and Marvin Natowicz, MD, PhD was awarded the LRI Excellence Award for Outstanding Educator • Kristi Benett, PhD and Ying Ni, MS were both awarded entry into the AAAS/Excellence in Science Program award for 2008-2009 State of the GMI 49

  50. Stacy Williams and Crystal Sterling were awarded the McNair Undergraduate Summer Research Scholarship for Minority Students Excelling in the Sciences Awards & Honors • Shireen Ganapathi was awarded the American Cancer Society Joseph F. Silber Undergraduate Research Fellowship • Guillaume Assie, MD, PhD was named a Finalist for the Cotterman Award for Best Trainee-First Authored Paper published in Am J Hum Genet • Rebecca Mitchell, RN and Patricia Pritchard were awarded LRI Star Awards in 2008 CONGRATULATIONS State of the GMI 50

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