1 / 11

Antimykotika: aktuelle og nye

Antimykotika: aktuelle og nye. Candida. Maiken Arendrup. Mykologisk afsnit. mad@ssi.dk SSI. C. albicans. Non-alb. Antimykotika. Cellevæg ß-1,3 glucan. -. Caspofungin. Lanosterol. Ergosterol. Cyt P450. -. Amfotericin B. -. -. -. Azoler: 1’ og 2’ Flu- itra- og ketoconazol

lionel
Download Presentation

Antimykotika: aktuelle og nye

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Antimykotika: aktuelle og nye Candida Maiken Arendrup. Mykologisk afsnit. mad@ssi.dk SSI. C. albicans Non-alb

  2. Antimykotika Cellevæg ß-1,3 glucan - Caspofungin Lanosterol Ergosterol Cyt P450 - Amfotericin B - - - • Azoler: 1’ og 2’ • Flu- itra- og ketoconazol • Voriconazol 5-FC Allylaminer

  3. Antimykotika spektrum: Gærsvampe

  4. Antimykotika spektrum: andre

  5. Farmakokinetik: voksne

  6. Famakodynamik Andes, AAC, 2003

  7. Candida susceptibility i Biofilm Ramage, AAC. 2002; Lewis, AAC 2002.

  8. Candidæmi, CVK’s betydning • 189 episoder af candidæmi, 123 med CVK. Mortalitet: • Fortsat CVK (65% vs. 23%) Luzzati R. Eur J Clin Microbiol Infect Dis 2000 • 164 episoder af candidæmi. Mortalitet: • CVK > 2 uger (OR 3,55) Gottfredsson. SSAC møde 2000 . • 104 episoder af candidæmi blandt neonatale. Karlowicz. Pediatrics. 2000

  9. Proteinsyntese elongationsfaktor 2 Iso-leucyl-tRNA synthetase Cyt P450 hsp90 Nye Antimykotika • Candiner • Micafungin og Anidulafungin • HMR 3270 • Sordariner • Glaxo - • ß-amino acids • PLD-118 • Polyener • Nyotran(nystatin) - • Efflux Pump Inhibitor • Milbemycin - - - • Chitinsyntase hæm. • Nikkomycin Z • Nye Azoler • Posaconazole og Ravuconazole • T-8581, D0870, UR-9746/ 9751, KP-103 - Mycograb

  10. Antimykotika spektrum: future drugs

  11. Konklusion • Antimykotika  • 4 klasser til systemiske infektioner • 5 nye klasser på vej • Store forskelle • Spektrum • Toxicitet • PK og PD forhold • Proteinbinding • Pris • Biofilm associeret Candida øget resistens

More Related