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Fiziologia cresterii

Fiziologia cresterii. Doua Etape de crestere rapida : in primul an de viata la pubertate , mai precoce la fete Determinata genetic + factori :

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Fiziologia cresterii

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  1. Fiziologiacresterii DouaEtape de crestererapida: in primul an de viatala pubertate, maiprecoce la fete Determinatagenetic + factori: 1 . Exogeni: alimentatia!!!proteine , aaesentiali, vitamine, minerale+ aportcaloric:glucide, lipide) ; bolileinfectioase 2.Endogeni-HORMONI 1.STH : hipofizectomiasisteazacresterea +STH +hormonitiroidieni-!!! Se reiacresterea HT potenteazaactiuneasomatomedine 2.Hormonii tiroidieni :favorizeazasinteza de STH simARN in celulehipofizare. HT in exces !! Catabolism ROL: crestereadintilor; osificareacartilajelor;dezvoltareaproportionala organism; maturareaexpresieifete. 3.Insulina: anabolism !! Diabetzaharat la copiltratament cu insulina. 4.H.sexuali-androgeni puseu de crestere la pubertate EFECT ANABOLiZANTproteic ; Accelerareacrestreriila pubertatesecretiaandogeni din CSR; STH; IGF. H.Androgeniinitiazacresterea la pubertate + osificareacartilajelordecrestere 5. Estrogenidoze micistimuleazacresterea ; in doze mariinhibacresterea 6.H.gliococorticoizi: inhibacresterea: catabolism proteic :inhibaactivitateasomatomedinelor

  2. HIPOFIZA POSTERIOARAnu are structura de” glanda”-terminatiinervoase , celulegliale, capilare,tesutconjunctivADH,oxitocina-9 aa; 1000dalt. • Nucleiisupraoptici –paraventriculari-neuronimagnocelulari –tract hipotalamohipofizarsecreta ADH , oxitocina-granule de secretia in neuroni -tract hipotalamohipofizar–transport axoplasmatic – potentiale de actiune-exocitoza Ca++ dependenta • Stimulare-stimulareazoneimamelonare-eliberare de Oxitocina –crestereapresiunii in canalelegalactofore –ejectialaptelui • Stimulareaneuronisecretorivasopresina –hipovolemie- descarcare FAZICA se impulsuri –descarcareprelungita de ADH • In granule hormonisi un polipeptidNeurofizina???-precusor de hormoni; carauspentruhormoni • ADH—echlibrulhidric+ reglarea TA –efectevasoconstrictoare • RECEPTORI : V1 mediazavasoconstrictia; Ca-calmodulina; V2 celulatubulararenala –cAMP-crestereapermeabilitaiipentruapa

  3. Reglareasecretia de ADH • -Stimulosmotici-cresterea PO >285mosm/l –stimulareaosmoreceptorilor din hipotalamus-secretia de ADH-reabsorbtia de apa –restabilesteechilibrul osmotic +stimulareaCentrulSetei- ingestia de apa- scadepresiuneaosmotica • -Variatiavolumulsanguin- crestereavolemie- distensiaatriilor-n X-bulb- hipotalamus-inhibasecretia de ADH-crestediureza- scadevolemia • Expunere la frig- scade ADH- vasoconstrictie – afuxvenoscrescut-crestediureza Ortostatism,hipovolemie- crestesecretia de ADH -scadediureza -Angiotensina II –stimuleazacentrulsetei- crestesecretia de ADH

  4. OXITOCINA • Oxus-rapid; tokos-nastere • 1.contractia musculaturii uterine :declanseaza contractile uterine la nastere; stimulareazoneimamelonare+ coluluiuterincrestesecretia de oxitocina-contractiamusculaturii uterine • Sensibilitateamusculaturii uterine la oxitocina –creste-estrogeni; scade la progesteron • 2.contractia celulelormioepitelialedin canalelegalactofore-ejectialaptelui

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