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Alpha- ketoglutarat dehidrogenase kompleks

Alpha- ketoglutarat dehidrogenase kompleks. Oleh : Kelompok 5 Tivani Kamalia A Febi Vania Sofyan Elevia Febriani Mirra Novyanti Bonita Ayu Andhira Nisa Aulia. Pendahuluan.

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Alpha- ketoglutarat dehidrogenase kompleks

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  1. Alpha-ketoglutaratdehidrogenasekompleks Oleh : Kelompok 5 TivaniKamalia A FebiVaniaSofyan EleviaFebriani MirraNovyanti BonitaAyuAndhira NisaAulia

  2. Pendahuluan • Padasiklusasamsitrat, reaksiisositratmenjadialfa-ketoglutaratolehbantuanenzimisositratdehidrogenase. • Alfa-ketoglutaratmengalamidekarboksilasimenjadisuksinilko-A denganbantuanenzimalfa-ketoglutaratdehidrogenasekompleks.

  3. SiklusAsamSitrat

  4. ProsesReaksi • a-ketoglutaratkehilangan 1 molekul CO2kemudianditambahkankoenzim A. • ReaksidekarboksilasiOksidatifterjadidenganbantuankoenzim NAD+ yang diubahmenjadi NADH. • Enzim yang berperanadalahkompleksenzimalfa-ketoglutaratdehidrogenase.

  5. PersamaanReaksi

  6. Aktivitas Faktor yang mempengaruhiaktivitasenzim Alpha-KetoglutaratDehidrogenase (KGDHC): • Suhu optimum 37°C • pH optimum 7 • Konsentrasisubstrat • Konsentrasienzim • Aktivator • Inhibitor

  7. AKTIVITAS • Penurunanaktivitasenzim KGDHC menyebabkangangguansel-selotakdikarenakanfungsimitokondria yang abnormal. • Reduksidarienziminikemungkinanmeyebabkansellebihrentandandapatmenyebabkankematian sel.

  8. Aktivator • Aktivator: Koenzim TPP (Thyaminepyrophospate) diperlukandalamreaksipembentukansuksinil-coA. • Koenzimygdiperlukanantara lain: Koenzim A, NAD+, danTPP.

  9. INHIBITOR • Inhibitor: senyawakompleksretenon yang merupakanturunankelompokisoflavondapatmenghambataktivitasenzim Alpha-KetoglutaratDehidrogenase.

  10. MekanismeReaksi

  11. LanjutanMekanismeReaksi

  12. TERIMAKASIH 

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