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Leksioni 28

Leksioni 28. Oksidimi I acideve yndyrore te pangopura. Acidet yndyrore te pangopura oksidohen nga e njejta rruge metabolike . Por ekzistojne 2 probleme : 1. lidhjet dyfishe ne acidet yndyrore jane te konfiguracionit Cis , ndersa gjate B- oksidimit formohet transenoil coa .

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Leksioni 28

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  1. Leksioni 28 Oksidimi I acideveyndyroretepangopura.

  2. Acidetyndyroretepangopuraoksidohennga e njejtarrugemetabolike. • Porekzistojne 2 probleme : • 1. lidhjetdyfishe ne acidetyndyrorejanetekonfiguracionitCis, ndersagjate B-oksidimitformohettransenoilcoa. • 2. GjatelargimittenjesiveprejdyatomekarboniformohetnjeacilCoAcis e pangopur.

  3. Per tesqaruarketodyproblemestudiojmeoksidimin e acideveyndyroremonoenoikedhepolienoike. • Marrimpshacidinoleik, nje acid monoenoik me 18 atomekarboni. • Trembetjet e parateacetilCoAshkeputen me rrugen e zakonshmeteBoksidimit. FormohetcisenoilCoA.

  4. OleilCoA CisenoilCoA + 3 acetilCoA • Cisenoilcoaqeformohetnukeshteprodukt normal I reaksionitte b-oksidimit. • Ajonukmundtevazhdojerrugen e metejshmemetabolike. • Per teberetemundurperdorimin e sajduhettenderhyjenjeenzimendihmesedheeshtepikerishtnjeizomerazespecifike.

  5. KjoizomerazeshnderroncisenoilcoA ne trans enoilCoA.

  6. Trans enoilcoavazhdonrrugennormaleteshnderrimevetemetejshme. • Pra, oksidimi I acideveyndyroremonoenoikekerkonnjeenzimeshteze. • Marrimshembullin e njeacidipolienoil, pshacidilinoleikqe ka 18 atome C. • Ngashkeputja e 3 mbetjeveteacetilcoAformohetcisdienoilCoA.

  7. Ketuvepronizomerazaashtusikursetekrasti I acidevemonoenoikedheformohet trans, cis, dienoilCoA. • Ngakjoperberje me rrugenormalete B-oksidimitshkeputen 2 mbetjetetjerateacetilCoAdheformohencisenoilCoA. • Kjohidratohetnenveprimin e enoilCoAhidratazesdhe ne keterastformohetstereoizomeri I 3 hidroksiacilCoA.

  8. Mirepo, enzimapasuese e b-oksidimit (hidroksiacildehidrogenaza) eshteabsolutishtspecifike per L-izomerin. • Kjo do tethoteqetegjitha D-izomeretnukmundtesherbejnesisubstrat I kesajenzime. Ne kete cast nderhynnjetjeterenzimendihmeseqenukeshtgjetjetervecsenjeepimerazespecifike, e cilakalon D-3 hidroksiacilCoa ne L-3 hidroksiacilCoa.

  9. Me pas vazhdonrruganormale e B-oksidimit. .

  10. Oksidimi I acideveyndyrore me nr tekatomesh C. • Ne organizmin e njeriutmbizoterojne ALY me numerciftatomesh C. Poratyndodhen ne sasitevogeledhe ALY me nr tekatomeshKarboni. • Ketoacideaktivizohendhetransportohen ne mitokondri ne menyretengjashme me ALY me nr ciftteatomeve C. • Atogjithashtu I nenshtrohen Beta-oksidimitsikurse ALY me nr cift C.

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